DNA 甲基转移酶（DNMTs）在转移中的作用。

Role of DNA Methyltransferases (DNMTs) in metastasis.

机构信息

Deanship of Educational Services, Department of Biochemistry, Qassim University, Buraydah, Saudi Arabia.

Scientific Center for Innovative Technologies and Research, Kazakhstan.

出版信息

Cell Mol Biol (Noisy-le-grand). 2022 May 22;68(1):226-236. doi: 10.14715/cmb/2022.68.1.27.

DOI:10.14715/cmb/2022.68.1.27

PMID:35809309

Abstract

The DNA methyltransferase (DNMT) family constitutes a conserved set of DNA-modifying enzymes which have essential functions in the modulation of epigenetics. The fundamental role of epigenetic changes in carcinogenesis and metastasis is increasingly being appreciated. DNMTs (DNMT1, DNMT3A and DNMT3B) have been shown to drive metastasis. Epigenetic machinery is installed at the target sites for the regulation of a wide variety of genes. Moreover, microRNAs, long non-coding RNAs and circular RNAs also shape the epigenetic landscape during metastasis. In this review, we have provided a snapshot of the quintessential role of DNMTs in metastasis. We also summarize how lncRNAs and circRNAs play roles in the epigenetic regulation of a myriad of genes.

摘要

DNA 甲基转移酶（DNMT）家族构成了一组保守的 DNA 修饰酶，它们在表观遗传学的调节中具有重要功能。表观遗传变化在癌症发生和转移中的基本作用正日益受到重视。DNMTs（DNMT1、DNMT3A 和 DNMT3B）已被证明可促进转移。表观遗传机制被安装在靶位点，以调节各种基因。此外，microRNAs、长非编码 RNA 和环状 RNA 也在转移过程中形成表观遗传景观。在这篇综述中，我们提供了一个关于 DNMT 在转移中核心作用的快照。我们还总结了 lncRNAs 和 circRNAs 如何在众多基因的表观遗传调控中发挥作用。