Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, China.
Anhui Prevention and Treatment Center for Occupational Disease, Anhui No. 2 Provincial People's Hospital, Hefei 230022, China.
Ecotoxicol Environ Saf. 2022 Sep 1;242:113858. doi: 10.1016/j.ecoenv.2022.113858. Epub 2022 Jul 6.
Carbon nanotubes (CNTs) have become far and wide used in a number of technical and merchant applications as a result of substantial advances in nanotechnology, therein single-walled carbon nanotubes (SWCNT) are one of the most promising nanoparticles. Inhaling CNTs has been linked to a variety of health problems, including lung fibrosis. Glycyrrhetinic acid 3-O-mono-β-D-glucuronide (GAMG), a natural sweetener, has anti-inflammatory and antioxidant capacities. The purpose of this study was to evaluate the potential for GAMG to alleviate SWCNT-induced lung inflammation and fibrosis. During days 3-28 after SWCNT intratracheal administration, we observed a remarkable increase of IL-1β, IL-6 and TNF-α in bronchoalveolar lavage fluid (BALF) on day 3 and collagen deposition on day 28. GAMG treatment remarkably ameliorated SWCNT-induced pulmonary fibrosis and attenuated SWCNT-induced inflammation and collagen deposition, and suppressed the activation of PI3K/AKT/NF-κB signaling pathway in the lungs. Therefore, GAMG has a therapeutic potential for the treatment of SWCNT-induced pulmonary fibrosis. Targeting PI3K/AKT/NF-κB signaling pathway may be a potential therapeutic approach to treat pulmonary fibrosis in mice with SWCNT.
碳纳米管（CNTs）由于纳米技术的重大进展，在许多技术和商业应用中得到了广泛的应用，其中单壁碳纳米管（SWCNT）是最有前途的纳米颗粒之一。吸入 CNTs 与多种健康问题有关，包括肺纤维化。甘草次酸 3-O-单-β-D-葡萄糖醛酸（GAMG）是一种天然甜味剂，具有抗炎和抗氧化作用。本研究旨在评估 GAMG 缓解 SWCNT 诱导的肺炎症和纤维化的潜力。在 SWCNT 气管内给药后的第 3-28 天，我们观察到第 3 天支气管肺泡灌洗液（BALF）中 IL-1β、IL-6 和 TNF-α 显著增加，第 28 天胶原沉积。GAMG 治疗显著改善了 SWCNT 诱导的肺纤维化，减轻了 SWCNT 诱导的炎症和胶原沉积，并抑制了肺部 PI3K/AKT/NF-κB 信号通路的激活。因此，GAMG 具有治疗 SWCNT 诱导的肺纤维化的潜力。靶向 PI3K/AKT/NF-κB 信号通路可能是治疗 SWCNT 诱导的小鼠肺纤维化的一种潜在治疗方法。
