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甘草酸对先天性巨结肠相关小肠结肠炎斑马鱼的干预作用及相关机制

Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis.

作者信息

Liu Ming-Kun, Chen Ying-Jian, Chen Fei, Lin Zhi-Xiong, Zhu Zi-Cheng, Lin Yu, Fang Yi-Fan, Wu Dian-Ming

机构信息

Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian Province, China.

Department of Pediatric Surgery, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350000, Fujian Province, China.

出版信息

World J Gastrointest Surg. 2023 Jul 27;15(7):1317-1330. doi: 10.4240/wjgs.v15.i7.1317.

DOI:10.4240/wjgs.v15.i7.1317
PMID:37555121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10405109/
Abstract

BACKGROUND

The prevention and treatment of Hirschsprung-associated enterocolitis (HAEC) is a serious challenge in pediatric surgery. Exploring the mechanism of HAEC is conducive to the prevention of this disease.

AIM

To explore the possible mechanism of glycyrrhizic acid (GA) and its therapeutic effect on HAEC.

METHODS

We developed a model of enteritis induced by trinitrobenzenesulfonic acid (TNBS) in zebrafish, and treated it with different concentrations of GA. We analyzed the effect of GA on the phenotype and inflammation of zebrafish.

RESULTS

After treatment with TNBS, the area of the intestinal lumen in zebrafish was significantly increased, but the number of goblet cells in the intestinal lumen was significantly reduced, but these did not increase the mortality of zebrafish, indicating that the zebrafish enteritis model was successfully developed. Different concentrations of GA protected zebrafish with enteritis. In particular, high concentrations of GA were important for the prevention and control of HAEC because it significantly reduced the intestinal luminal area, increased the number of goblet cells in the intestinal lumen, and reduced the levels of interleukin (IL)-1β and IL-8.

CONCLUSION

GA significantly reduced the intestinal luminal area, increased the number of intestinal goblet cells, and decreased IL-1β and IL-8 in zebrafish, and is important for prevention and control of HAEC.

摘要

背景

先天性巨结肠相关小肠结肠炎（HAEC）的防治是小儿外科面临的严峻挑战。探究HAEC的发病机制有助于预防该病。

目的

探讨甘草酸（GA）防治HAEC的可能机制及其治疗作用。

方法

我们建立了三硝基苯磺酸（TNBS）诱导的斑马鱼肠炎模型，并用不同浓度的GA进行处理。分析GA对斑马鱼表型和炎症的影响。

结果

TNBS处理后，斑马鱼肠腔面积显著增大，但肠腔内杯状细胞数量显著减少，且未增加斑马鱼死亡率，表明成功建立了斑马鱼肠炎模型。不同浓度的GA对患肠炎的斑马鱼有保护作用。特别是高浓度的GA对HAEC的防治具有重要意义，因为它能显著减小肠腔面积，增加肠腔内杯状细胞数量，并降低白细胞介素（IL）-1β和IL-8水平。

结论

GA可显著减小斑马鱼肠腔面积，增加肠道杯状细胞数量，并降低IL-1β和IL-8水平，对HAEC的防治具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/6739f4e3d5f6/WJGS-15-1317-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/b023085fb446/WJGS-15-1317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/1391a102e268/WJGS-15-1317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/85cdf801963f/WJGS-15-1317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/02a913a323af/WJGS-15-1317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/f0ec651338e5/WJGS-15-1317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/9d8bdfe8c0aa/WJGS-15-1317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/04758489ad9b/WJGS-15-1317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/6739f4e3d5f6/WJGS-15-1317-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/b023085fb446/WJGS-15-1317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/1391a102e268/WJGS-15-1317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/85cdf801963f/WJGS-15-1317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/02a913a323af/WJGS-15-1317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/f0ec651338e5/WJGS-15-1317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/9d8bdfe8c0aa/WJGS-15-1317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/04758489ad9b/WJGS-15-1317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cd1/10405109/6739f4e3d5f6/WJGS-15-1317-g008.jpg

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本文引用的文献

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