Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi Province, China.
Department of the First People's Hospital of Jingdezhen, Jiangxi Province, China.
Clin Neurophysiol. 2022 Sep;141:24-33. doi: 10.1016/j.clinph.2022.06.007. Epub 2022 Jun 22.
This study aimed to evaluate the predictive value of quantitative electroencephalography (QEEG) in the outcome of patients with acute ischemic stroke (AIS) who underwent mechanical thrombectomy (MT) and to assess the correlation between clinical outcome and QEEG and CT perfusion (CTP) data.
Twenty-nine MT patients were included in this prospective study. Continuous electroencephalography (EEG) monitoring was performed, in which delta power, the δ/α ratio (DAR), and the (θ + δ)/(α + β) ratio (DTABR) were calculated. The clinical scores at different points were recorded. Based on the modified Ranking scale, the patients were divided into good and poor outcome groups. Several CTP parameters were recorded before MT. The correlation between QEEG, CTP parameters, and clinical scores was analyzed using the Spearman correlation analysis. The predictive value of QEEG indices and CTP parameters for the 3-month outcome was compared using the receiver operating characteristic (ROC) curve.
Delta power except for 7 days after MT, DAR, DATBR, and several CTP parameters were all significantly associated with the clinical scores. Although some CTP parameters were associated with the clinical scores, they were less powerful than QEEG in predicting a good or poor outcome at 3 months. Among the different explored EEG indicators, the predictive value of delta 24 h after MT was the highest.
QEEG indices may have a certain predictive value for the outcome of AIS patients who underwent MT.
QEEG may become a new prognostic tool in AIS patients who underwent MT, facilitating the planning and management of related rehabilitation plans.
本研究旨在评估接受机械取栓术（MT）的急性缺血性脑卒中（AIS）患者定量脑电图（QEEG）的预后预测价值，并评估临床结果与 QEEG 和 CT 灌注（CTP）数据之间的相关性。
本前瞻性研究纳入了 29 例 MT 患者。进行连续脑电图（EEG）监测，计算δ功率、δ/α 比值（DAR）和（θ+δ）/（α+β）比值（DTABR）。记录不同时间点的临床评分。根据改良Rankin 量表，将患者分为预后良好和预后不良组。记录 MT 前的几个 CTP 参数。采用 Spearman 相关分析分析 QEEG、CTP 参数与临床评分之间的相关性。采用受试者工作特征（ROC）曲线比较 QEEG 指标和 CTP 参数对 3 个月预后的预测价值。
除 MT 后 7 天外，δ功率、DAR、DATBR 和几个 CTP 参数均与临床评分显著相关。虽然一些 CTP 参数与临床评分相关，但它们在预测 3 个月时的良好或不良预后方面的作用不如 QEEG。在探索的不同 EEG 指标中，MT 后 24 小时的δ波具有最高的预测价值。
QEEG 指数可能对接受 MT 的 AIS 患者的预后有一定的预测价值。
QEEG 可能成为接受 MT 的 AIS 患者的一种新的预后工具，有助于相关康复计划的规划和管理。
