Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang 421001, China.
Clin Chim Acta. 2022 Sep 1;534:22-28. doi: 10.1016/j.cca.2022.07.004. Epub 2022 Jul 7.
Atherosclerosis, a chronic inflammatory disease, is a leading cause of death worldwide. Vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs) and macrophages play extremely vital roles in the formation of atherosclerotic plaques and subsequent atherosclerosis. Necroptosis, a caspase-independent programmed cell necrosis, occurs in advanced atherosclerotic plaques and has been implicated in VEC, VSMC and macrophage function. Although necroptosis may have considered as a defensive line against intracellular infection, it can induce a pro-inflammatory state, which will accelerate the disease process. Accordingly, necroptosis plays an important pathophysiologic role. In this review, we explore the role of necroptosis in VECs, VSMCs and macrophages in atherosclerotic plaques and their connection to atherosclerosis.
动脉粥样硬化是一种慢性炎症性疾病，是全球范围内主要的致死原因。血管内皮细胞（VECs）、血管平滑肌细胞（VSMCs）和巨噬细胞在动脉粥样硬化斑块的形成和随后的动脉粥样硬化中起着至关重要的作用。坏死性凋亡是一种不依赖半胱天冬酶的程序性细胞坏死，发生在晚期动脉粥样硬化斑块中，并与 VEC、VSMC 和巨噬细胞的功能有关。尽管坏死性凋亡可能被认为是对抗细胞内感染的防御线，但它可以诱导促炎状态，从而加速疾病进程。因此，坏死性凋亡在病理生理学中起着重要作用。在这篇综述中，我们探讨了坏死性凋亡在动脉粥样硬化斑块中的 VECs、VSMCs 和巨噬细胞中的作用及其与动脉粥样硬化的关系。
