Chang Xindi, Wang Bei, Zhao Yingli, Deng Bing, Liu Ping, Wang Yiru
Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wan-Ping Road, Shanghai, China.
Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wan-Ping Road, Shanghai, China.
Cell Death Discov. 2024 May 1;10(1):204. doi: 10.1038/s41420-024-01978-5.
Interferon Gamma Inducible Protein 16 (IFI16) belongs to the HIN-200 protein family and is pivotal in immunological responses. Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis, apoptosis, and necroptosis. Notably, these processes are integral to the emergent concept of PANoptosis, which encompasses cellular demise and inflammatory pathways. Current research implies a significant regulatory role for IFI16 in PANoptosis, particularly regarding cardiac pathologies. This review delves into the complex interplay between IFI16 and PANoptosis in heart diseases, including atherosclerosis, myocardial infarction, heart failure, and diabetic cardiomyopathy. It synthesizes evidence of IFI16's impact on PANoptosis, with the intention of providing novel insights for therapeutic strategies targeting heart diseases.
γ干扰素诱导蛋白16（IFI16）属于HIN-200蛋白家族，在免疫反应中起关键作用。作为一种DNA传感器，IFI16可识别病毒DNA和异常DNA，触发免疫和炎症反应。它参与多种细胞死亡机制，如焦亡、凋亡和坏死性凋亡。值得注意的是，这些过程是PANoptosis这一新兴概念的组成部分，PANoptosis涵盖了细胞死亡和炎症途径。目前的研究表明IFI16在PANoptosis中具有重要的调节作用，尤其是在心脏病理学方面。这篇综述深入探讨了IFI16与PANoptosis在心脏病（包括动脉粥样硬化、心肌梗死、心力衰竭和糖尿病心肌病）中的复杂相互作用。它综合了IFI16对PANoptosis影响的证据，旨在为针对心脏病的治疗策略提供新的见解。
