Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
J Ethnopharmacol. 2022 Oct 5;296:115521. doi: 10.1016/j.jep.2022.115521. Epub 2022 Jul 6.
During the treatment of diseases, histone deacetylases (HDAC) may have side effects such as strong immune inhibition and drug resistance, which may lead to damage of heart, liver and kidney. Traditional Chinese medicine (TCM) is a valuable and unique resource in China, which has good efficacy and safety. At present, it has been found that Chinese herbal compounds and active ingredients can effectively inhibit the expression of HDAC. Moreover, pharmacological studies have shown that these TCMs have shown therapeutic effects in the treatment of cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases and skin diseases.
This article reviews the mechanism of action of HDAC, and introduces the epigenetic correlation between TCM and HDAC. We expounded the histone deacetylase inhibitor (HDACi)-like inhibitory effect and clinical application of natural drugs, and summarized the research progress of TCM on HDAC in recent years.
We collected relevant information published before March 2022 by searching the literature in various online databases such as PubMed, CNKI, Wanfang Database, Elsevier, Web of Science and China Biomedical Database. Search terms include "HDAC" or "HDACi", as well as "herb" or "herbal ingredient".
A large number of studies have proved that many TCMs and their chemical components have the effect of inhibiting HDAC activity, which is highly selective, acts on different HDAC subtypes, and plays a certain therapeutic effect in cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases, skin diseases and other diseases by inhibiting the process of HDAC.
The review of this paper is helpful to understand and excavate the active components of TCM, further explore the role of plant drugs with HDACi-like effect in diseases, and provide ideas for the development of new HDACi.
在治疗疾病时，组蛋白去乙酰化酶（HDAC）可能会产生强烈的免疫抑制和耐药等副作用，从而导致心脏、肝脏和肾脏受损。中药（TCM）是中国宝贵而独特的资源，具有良好的疗效和安全性。目前，已发现中草药化合物和活性成分能有效抑制 HDAC 的表达。此外，药理研究表明，这些 TCM 在治疗癌症、心脑血管疾病、骨科疾病和皮肤病方面具有治疗作用。
本文综述了 HDAC 的作用机制，并介绍了 TCM 与 HDAC 之间的表观遗传学相关性。我们阐述了天然药物的组蛋白去乙酰化酶抑制剂（HDACi）样抑制作用和临床应用，并总结了近年来 TCM 对 HDAC 的研究进展。
通过检索 PubMed、CNKI、万方数据库、Elsevier、Web of Science 和中国生物医学文献数据库等多个在线数据库，收集截至 2022 年 3 月前发表的相关信息。检索词包括“HDAC”或“HDACi”，以及“草药”或“草药成分”。
大量研究证明，许多 TCM 及其化学成分具有抑制 HDAC 活性的作用，这种抑制作用具有高度选择性，作用于不同的 HDAC 亚型，通过抑制 HDAC 过程，在癌症、心脑血管疾病、骨科疾病、皮肤病等疾病中发挥一定的治疗作用。
本文的综述有助于了解和挖掘 TCM 的活性成分，进一步探索具有 HDACi 样作用的植物药物在疾病中的作用，为开发新型 HDACi 提供思路。
