Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6 and 33, 56126 Pisa, Italy.
Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6 and 33, 56126 Pisa, Italy.
Semin Cancer Biol. 2022 Nov;86(Pt 2):325-333. doi: 10.1016/j.semcancer.2022.07.003. Epub 2022 Jul 6.
Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the "Warburg effect", which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.
肿瘤长期以来一直被认为会重新调整其代谢以促进增殖、生长、存活和侵袭。这些改变的共同特征之一是增强葡萄糖摄取，并通过糖酵解将其随后转化为乳酸，而不管氧气的可用性或线粒体的效率如何。这种现象被称为“瓦伯格效应”，自从德国生理学家奥托·海因里希·瓦伯格（Otto Heinrich Warburg）首次发现以来，已经有一个世纪的历史了。从那时起，肿瘤中这种特殊的代谢转换已经通过涵盖多个研究领域的广泛研究来解决。在这个历史视角下，我们旨在说明这些研究随时间的演变及其在各个科学领域的意义。
