Belon P
Pathol Biol (Paris). 1978 May-Jun;26(5):225-31.
Seven glycosyl-transferases and the lactico-dehydrogenase from human aortas were assayed. These aortas were divided in five classes according to the age and in five steps according to the atherogenesis. These enzymic activities do not show any parallelism in their evolution; their variation with age and with atherogenesis is quite different. For example, the N-acetylgalactosaminyl-transferase activity increases with atherogenesis whereas it diminishes with age; on the other hand the lactate-dehydrogenase activity increases with age and decreases with atherogenesis; the sialyl-transferase activity is nearly constant during adulthood while it hardly declines with atherogenesis. These assays suggest: 1) an effect of energy metabolism on the glycosyl-transferase activities; 2) a qualitative and quantitative variation of the glycosaminoglycans biosynthesis; 3) a structural modification of the glucidic part of the glycoproteins which can induce the formation of antigenic sites.
对取自人类主动脉的七种糖基转移酶和乳酸脱氢酶进行了测定。这些主动脉根据年龄分为五类，根据动脉粥样硬化形成情况分为五个阶段。这些酶活性在其演变过程中未显示出任何平行关系；它们随年龄和动脉粥样硬化形成的变化差异很大。例如，N-乙酰半乳糖胺基转移酶活性随动脉粥样硬化形成而增加，却随年龄增长而降低；另一方面，乳酸脱氢酶活性随年龄增长而增加，随动脉粥样硬化形成而降低；唾液酸转移酶活性在成年期几乎保持恒定，而随动脉粥样硬化形成几乎不下降。这些测定结果表明：1）能量代谢对糖基转移酶活性有影响；2）糖胺聚糖生物合成在质量和数量上发生变化；3）糖蛋白糖部分的结构修饰可诱导抗原位点的形成。
