Guidollet J, Chignier E, Paul J, Belleville J, Louisot P, Descotes J
Paroi Arterielle. 1978 Apr;4(3):177-87.
Extrinsic local constraints, realised on dogs aorta are responsible for parietal lesions in the form of thickening of the arterial wall. Histological changes in the intima and media are characteristic of processes of degeneration destruction and cellular regeneration, superposed on sub-endothelial proliferation accompained by partial or total destruction of endothelial cells in the intimal layer. In addition to histological changes, there were perturbation in enzymatic activities of glycosyltransferases responsible for macromolecular constructions in the intima. Microsomic enzymes studied were: N-acetyl-glucosaminyl-transferase, sialyl-transferase and N-acetyl-galactosaminyl-transferase, and two glycosyl-transferases located in the soluble cytoplasmic phase: fucosyl and xylosyl-transferase. The changes observed were different according to the position of the sugars in the glycoprotein chains. For example the variation of fucosyl-transferase activity is significant: it disappears in group where the sialyl-transferase activity is enhanced. The transfer of xylose is decreased. Finally, changes observed in hexosaminyl-transferase activities were parallel.
作用于犬主动脉的外在局部约束是导致动脉壁增厚形式的壁层病变的原因。内膜和中膜的组织学变化具有变性破坏和细胞再生过程的特征，叠加在内皮下增殖之上，伴有内膜层内皮细胞的部分或全部破坏。除了组织学变化外，负责内膜中大分子构建的糖基转移酶的酶活性也存在紊乱。所研究的微粒体酶有：N-乙酰葡糖胺基转移酶、唾液酸转移酶和N-乙酰半乳糖胺基转移酶，以及位于可溶性细胞质相的两种糖基转移酶：岩藻糖基转移酶和木糖基转移酶。观察到的变化根据糖在糖蛋白链中的位置而不同。例如，岩藻糖基转移酶活性的变化很显著：在唾液酸转移酶活性增强的组中它消失了。木糖的转移减少。最后，己糖胺基转移酶活性的变化是平行的。
