Department of Dermatology, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Department of Pathology, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.
An Bras Dermatol. 2022 Sep-Oct;97(5):624-627. doi: 10.1016/j.abd.2021.10.006. Epub 2022 Jul 7.
Eccrine poroma is the term that includes benign neoplasms of the terminal duct of the eccrine sweat glands, which may clinically and dermoscopically resemble other melanoma and non-melanoma skin tumors. They are often located on the extremities (especially palms and soles), presenting as normochromic or erythematous papules and nodules, measuring up to 2 cm. Pigmented variants are uncommon, accounting for less than 20% of cases. This report describes a 37-year-old man who developed a large pigmented eccrine poroma on his right shoulder, causing diagnostic difficulty. Histopathological examination revealed a nodular neoplasm consisting of small, monomorphic, cuboidal cells, with ample, eosinophilic cytoplasm and well-defined borders, in addition to conspicuous intercellular bridges, with melanin deposits diffusely distributed inside them. The absence of cytological atypia, cellular pleomorphism, increased mitotic activity, and necrosis foci corroborated the diagnostic exclusion of porocarcinoma, which can develop from eccrine poroma.
汗管瘤是一种包括终端汗管腺良性肿瘤的术语，其临床表现和皮肤镜表现可能与其他黑色素瘤和非黑色素瘤皮肤肿瘤相似。它们通常位于四肢（尤其是手掌和脚底），表现为正常色素或红斑丘疹和结节，大小可达 2 厘米。色素变体较为罕见，不到病例的 20%。本报告描述了一位 37 岁男性，其右肩部出现了一个大型色素性汗管瘤，导致诊断困难。组织病理学检查显示一个结节状肿瘤，由小而形态单一的立方形细胞组成，胞质丰富，嗜酸性，边界清晰，此外还有明显的细胞间桥，其内弥漫分布有黑色素沉积。无细胞学异型性、细胞多形性、有丝分裂活性增加和坏死灶，这支持排除了可以从汗管瘤发展而来的汗管癌的诊断。
