Meriläinen Anna-Stiina, Sihto Harri, Isola Jorma, Koljonen Virve
Department of Surgery, The Central Hospital of Tavastia Proper, Hämeenlinna, Finland.
University of Helsinki, Helsinki, Finland.
PLoS One. 2025 May 30;20(5):e0324975. doi: 10.1371/journal.pone.0324975. eCollection 2025.
Eccrine poroma (EP) and porocarcinoma (EPC) arise from the intraepidermal part of the sweat gland. Clinically they resemble each other and cannot be distinguished without histopathological examination. EPC has been described as aggressive; however, the Ki-67 index is scarcely reported. The aim of this study was to compare clinicopathological factors between EP and EPC with special interest in Ki-67 index.
50 EP and 22 EPC samples with clinical data from 48 EP and 21 EPC patients were collected from the Finnish Biobanks. We performed immunohistochemistry using a Ki-67 antibody on a tissue microarray and analysed the Ki-67 index with ImmunoRatio 2.5-program. We analysed 48 EP and 21 EPC samples. EPC patients were older (p = 0.019) and their tumours larger (p = 0.003) but other than these there were no statistically significant differences. Ki-67 ratios were similar (medians: EP 0.6% and EPC 0.5%). The median follow-up time in EP group was 12 (range 1.5-30.6 years) and in EPC group 7 years (range 0.75-20.3 years). The survival of EP patients was better than EPC patients but did not reach statistical significance and, in the Cox multivariate analysis only age had statistically significant effect (HR 1.061, 95% CI 1.026-1.099, p < 0.001). Ki-67 index had no statistically significant effect on survival in EPC group in the Cox univariate analysis (HR 0.746, 95% CI 0.390-1.43, p = 0.378).
EPC patients were older and their tumours larger. There was no difference in Ki-67 index between EP and EPC groups. In the Cox multivariate analysis only age had a statistically significant effect on survival. According to our findings Ki-67 index might not be a decisive factor in the prognosis of EPC. Further studies to validate our current findings are warranted.
小汗腺汗孔瘤（EP）和汗孔癌（EPC）起源于汗腺的表皮内部分。临床上它们彼此相似，未经组织病理学检查无法区分。EPC被描述为侵袭性的；然而，Ki-67指数鲜有报道。本研究的目的是比较EP和EPC之间的临床病理因素，特别关注Ki-67指数。
从芬兰生物样本库收集了50例EP和22例EPC样本以及来自48例EP和21例EPC患者的临床数据。我们在组织芯片上使用Ki-67抗体进行免疫组织化学，并使用ImmunoRatio 2.5程序分析Ki-67指数。我们分析了48例EP和21例EPC样本。EPC患者年龄较大（p = 0.019），其肿瘤较大（p = 0.003），但除此之外没有统计学上的显著差异。Ki-67比率相似（中位数：EP为0.6%，EPC为0.5%）。EP组的中位随访时间为12年（范围1.5 - 30.6年），EPC组为7年（范围0.75 - 20.3年）。EP患者的生存率优于EPC患者，但未达到统计学显著性，并且在Cox多变量分析中只有年龄具有统计学显著影响（风险比1.061，95%置信区间1.026 - 1.099，p < 0.001）。在Cox单变量分析中，Ki-67指数对EPC组的生存率没有统计学显著影响（风险比0.746，95%置信区间0.390 - 1.43，p = 0.378）。
EPC患者年龄较大，其肿瘤较大。EP和EPC组之间的Ki-67指数没有差异。在Cox多变量分析中只有年龄对生存率有统计学显著影响。根据我们的研究结果，Ki-67指数可能不是EPC预后的决定性因素。有必要进行进一步研究以验证我们目前的发现。
