Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
J Alzheimers Dis. 2022;88(4):1639-1650. doi: 10.3233/JAD-220209.
Alzheimer's disease (AD) has been confirmed as an influencing factor of visual impairment, but potential concomitant effects on visual and cognitive performance are not well understood.
To provide a new method for early screening of Alzheimer's disease and further explore the theoretical mechanism of the decline of whole visual and cognitive performance in AD.
We studied 60 individuals without dementia as normal control (NC), 74 individuals with subjective cognitive decline (SCD), 60 individuals with amnesia mild cognitive impairment (aMCI), and 75 patients with AD on a battery of tests designed to measure multiple aspects of basic and higher-order visual perception and cognition. All subjects performed on same visual and cognitive test batteries.
The results showed both of four groups, with the stimulus-presentation time being longer, the visual-search performance improved, and both the eye interest-area first fixation duration and the interest-area-fixation count increased. Particularly under the noise-masking condition, the AD group performed the worst at stimulus-presentation times between 300 and 900 ms. The aMCI group, but not the SCD group, performed worse than the NC group at the stimulus-presentation time of either 300 or 500 ms. The interest-area-fixation count was higher in all the patient groups than that in the NC group, and distinguishable between participants with AD and those with SCD or aMCI.
The visual-search performance combined with eye-movement tracking under the noise-masking condition can be used for distinguishing AD from normal aging, SCD, and aMCI.
阿尔茨海默病（AD）已被证实是视力障碍的影响因素，但对其对视功能和认知表现的潜在伴发影响尚不清楚。
为 AD 的早期筛查提供新方法，并进一步探讨 AD 患者整体视功能和认知表现下降的理论机制。
我们研究了 60 名无痴呆的个体作为正常对照组（NC）、74 名有主观认知下降（SCD）的个体、60 名有遗忘型轻度认知障碍（aMCI）的个体和 75 名 AD 患者，使用旨在测量多个方面基本和高级视知觉和认知的成套测试进行评估。所有受试者均接受相同的视觉和认知测试。
结果表明，随着刺激呈现时间的延长，所有 4 组的视觉搜索表现均得到改善，眼兴趣区首次注视持续时间和兴趣区注视次数均增加。特别是在噪声掩蔽条件下，AD 组在 300 至 900ms 的刺激呈现时间下表现最差。与 NC 组相比，aMCI 组而非 SCD 组在 300 或 500ms 的刺激呈现时间下表现较差。与 NC 组相比，所有患者组的兴趣区注视次数均较高，且 AD 组与 SCD 组或 aMCI 组之间可区分。
在噪声掩蔽条件下，结合眼动追踪的视觉搜索表现可用于区分 AD 与正常老化、SCD 和 aMCI。
