Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.
J Alzheimers Dis. 2022;88(4):1523-1532. doi: 10.3233/JAD-220417.
The Hong Kong Brief Cognitive Test (HKBC), a brief instrument designed to screen for cognitive impairment in older adults, has been validated in Cantonese-speaking populations and has shown better performance than the Mini-Mental State Examination (MMSE) in detecting both mild and major neurocognitive disorder (NCD).
This study aimed to validate the HKBC for detecting patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) in a Mandarin-speaking Chinese population.
Two hundred forty-eight patients with aMCI, 67 patients with mild AD and 306 healthy controls (HCs) were recruited for this study and completed both the HKBC and the MMSE. The performance of the HKBC and MMSE in distinguishing patients with aMCI from HCs and distinguishing patients with AD from patients with aMCI was compared in the whole population and in age- and education-stratified subgroups.
The optimal HKBC cutoff score for distinguishing patients with aMCI from HCs was 23, and the optimal cutoff score for distinguishing patients with AD from patients with aMCI was 17. The HKBC significantly outperformed the MMSE at differentiating patients with aMCI from HCs in the whole population (z = 12.38, p < 0.01) and all subgroups stratified by age or education. Regarding the discrimination of patients with AD from patients with aMCI, the HKBC showed better performance than the MMSE in the oldest subgroup (z = 2.18, p = 0.03).
The HKBC is a sensitive and specific screening tool for detecting aMCI and AD in the Chinese population across age groups and educational levels.
香港简明认知测试（HKBC）是一种用于筛查老年人认知障碍的简短工具，已在粤语人群中得到验证，并在检测轻度和重度神经认知障碍（NCD）方面表现优于简易精神状态检查（MMSE）。
本研究旨在验证 HKBC 在中国普通话人群中用于检测遗忘型轻度认知障碍（aMCI）和阿尔茨海默病（AD）患者的能力。
本研究共纳入 248 例 aMCI 患者、67 例轻度 AD 患者和 306 例健康对照者（HCs），他们均完成了 HKBC 和 MMSE 测试。比较了 HKBC 和 MMSE 在整个人群以及按年龄和教育程度分层的亚组中区分 aMCI 患者与 HCs 以及区分 AD 患者与 aMCI 患者的性能。
HKBC 区分 aMCI 患者与 HCs 的最佳截断值为 23，区分 AD 患者与 aMCI 患者的最佳截断值为 17。HKBC 在整个人群（z=12.38，p<0.01）和按年龄或教育程度分层的所有亚组中，在区分 aMCI 患者与 HCs 方面均显著优于 MMSE。在年龄最大的亚组中，HKBC 在区分 AD 患者与 aMCI 患者方面的表现优于 MMSE（z=2.18，p=0.03）。
HKBC 是一种敏感且特异性的筛查工具，可用于检测中国人群中不同年龄组和教育程度的 aMCI 和 AD。
