肌动蛋白异构体与金鱼红瘤细胞诱导的色素沉着变体中运动反应表达的关联。
An association of actin isoforms with the expression of motile response in pigmentation variants induced from goldfish erythrophoroma cells.
作者信息
Akiyama T, Matsumoto J, Tchen T T
出版信息
Cell Differ. 1987 Apr;20(4):271-7. doi: 10.1016/0045-6039(87)90472-6.
PMID:3581173
Abstract
Comparison of actin isoforms in unpigmented goldfish cells (a normal dermal fibroblast-like cell line, and an unpigmented erythrophoroma cell line capable of being induced to undergo melanization) and in normal and neoplastic melanized goldfish cells shows that the melanized phenotype is accompanied by the presence of multiple actin isoforms. In contrast, the unpigmented cells have only beta-actin. The possible significance of this to pigment organelle translocation is discussed.
摘要
无色素金鱼细胞（一种正常的真皮成纤维细胞样细胞系，以及一种能够被诱导进行黑色素化的无色素红细胞瘤细胞系）与正常和肿瘤性黑色素化金鱼细胞中肌动蛋白同工型的比较表明，黑色素化表型伴随着多种肌动蛋白同工型的存在。相比之下，无色素细胞仅含有β-肌动蛋白。文中讨论了这一点对色素细胞器易位的可能意义。
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