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Am J Cancer Res. 2022 Jun 15;12(6):2673-2685. eCollection 2022.
2
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本文引用的文献

1
Tumor treating fields can effectively overcome trastuzumab resistant breast cancer multiplication.肿瘤治疗电场可有效克服曲妥珠单抗耐药性乳腺癌的增殖。
Am J Cancer Res. 2021 Aug 15;11(8):3935-3945. eCollection 2021.
2
Tumor Treating Fields: At the Crossroads Between Physics and Biology for Cancer Treatment.肿瘤治疗电场：癌症治疗中物理学与生物学的交叉点
Front Oncol. 2020 Oct 30;10:575992. doi: 10.3389/fonc.2020.575992. eCollection 2020.
3
Sorafenib increases tumor treating fields-induced cell death in glioblastoma by inhibiting STAT3.索拉非尼通过抑制信号转导和转录激活因子3（STAT3）增强肿瘤治疗电场诱导的胶质母细胞瘤细胞死亡。
Am J Cancer Res. 2020 Oct 1;10(10):3475-3486. eCollection 2020.
4
Quantitation of the ROS production in plasma and radiation treatments of biotargets.定量检测生物靶区的血浆和辐射处理中的 ROS 产生。
Sci Rep. 2019 Dec 27;9(1):19837. doi: 10.1038/s41598-019-56160-0.
5
Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy.索拉非尼作为一种肿瘤治疗电场增敏剂的功能生物学活性用于治疗脑胶质瘤。
Int J Mol Sci. 2018 Nov 21;19(11):3684. doi: 10.3390/ijms19113684.
6
The role of different adjuvant therapies in locally advanced gastric adenocarcinoma.不同辅助治疗在局部晚期胃腺癌中的作用。
Oncotarget. 2018 Sep 21;9(74):34022-34029. doi: 10.18632/oncotarget.26106.
7
Selective toxicity of tumor treating fields to melanoma: an in vitro and in vivo study.肿瘤治疗电场对黑色素瘤的选择性毒性：一项体外和体内研究。
Cell Death Discov. 2018 Oct 3;4:46. doi: 10.1038/s41420-018-0106-x. eCollection 2018.
8
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.早期和局部晚期非小细胞肺癌（NSCLC）：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222.
9
Tumor-Treating Fields: A Fourth Modality in Cancer Treatment.肿瘤电场治疗：癌症治疗的第四种模式。
Clin Cancer Res. 2018 Jan 15;24(2):266-275. doi: 10.1158/1078-0432.CCR-17-1117. Epub 2017 Aug 1.
10
Combination therapy in combating cancer.癌症治疗中的联合疗法。
Oncotarget. 2017 Jun 6;8(23):38022-38043. doi: 10.18632/oncotarget.16723.

多柔比星联合肿瘤治疗电场（TTFields）与放疗：对抗肺癌的新方法

Combination therapy of Doxorubicin with TTFields and radiation: newer approaches to combat lung cancer.

作者信息

Lee Won Seok, Kim Eun Ho

机构信息

Department of Biochemistry, School of Medicine, Daegu Catholic University 33 17-gil, Duryugongwon-ro, Nam-gu, Daegu 427-724, Korea.

出版信息

Am J Cancer Res. 2022 Jun 15;12(6):2673-2685. eCollection 2022.

PMID:35812042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9251682/
Abstract

BACKGROUND

Tumor-treating fields (TTFields) have been used singly or with chemoradiation for treating glioblastoma and mesothelioma but not yet for lung cancer. Survival rates in lung cancer remain abysmal despite advances in early diagnosis and targeted therapies.

AIMS AND OBJECTIVES

We aimed to investigate the effectiveness of TTFields in inhibiting lung cancer growth and metastasis, as well as the therapeutic effectiveness of TTFields alongside radiation and chemosensitivity-enhancing agents in an in vitro model.

METHODS

We generated TTFields yielding 0-800 V sine-wave signals, 0.9 V/cm applied electric field intensity, and 150 kHz frequency. The human lung cancer cell lines A549 and H460 were used in this study. Cell viability, colony formation, cell death detection, and cell invasion assays were performed to assess the therapeutic effectiveness of TTFields; sensitization of lung cancer cells to TTFields by doxorubicin (DOX); and the combined effect of TTFields, DOX, and irradiation (IR).

RESULTS

Lung cancer cells showed a nearly 20% decrease in cell viability at 1 V/cm and 150 kHz. In A549 and H460 cells, TTFields increased apoptosis through increased cleaved caspase3, hindered cell migration and invasion, and improved chemosensitivity to DOX. The combination of DOX and TTFields showed better antitumor results than those of each individually. However, the DOX/TTFields/IR combination was most effective in reducing the viability and migration of lung cancer cells.

CONCLUSION

TTFields as an adjuvant therapy offers probability for improving lung cancer patient outcomes.

摘要

背景

肿瘤治疗电场（TTFields）已单独或与放化疗联合用于治疗胶质母细胞瘤和间皮瘤，但尚未用于肺癌治疗。尽管早期诊断和靶向治疗取得了进展，但肺癌的生存率仍然很低。

目的

我们旨在研究肿瘤治疗电场在抑制肺癌生长和转移方面的有效性，以及在体外模型中肿瘤治疗电场与放疗和化疗增敏剂联合使用的治疗效果。

方法

我们生成了能产生0 - 800V正弦波信号、0.9V/cm的施加电场强度和150kHz频率的肿瘤治疗电场。本研究使用了人肺癌细胞系A549和H460。进行细胞活力、集落形成、细胞死亡检测和细胞侵袭试验，以评估肿瘤治疗电场的治疗效果；阿霉素（DOX）对肺癌细胞对肿瘤治疗电场的增敏作用；以及肿瘤治疗电场、阿霉素和照射（IR）的联合作用。

结果

在1V/cm和150kHz时，肺癌细胞的细胞活力下降了近20%。在A549和H460细胞中，肿瘤治疗电场通过增加裂解的caspase3来增加细胞凋亡，阻碍细胞迁移和侵袭，并提高对阿霉素的化疗敏感性。阿霉素和肿瘤治疗电场联合使用显示出比单独使用更好的抗肿瘤效果。然而，阿霉素/肿瘤治疗电场/照射联合使用在降低肺癌细胞活力和迁移方面最有效。

结论

肿瘤治疗电场作为辅助治疗为改善肺癌患者的预后提供了可能性。