• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

负载阿贝西利的乙基纤维素基纳米海绵对MCF-7和MDA-MB-231人乳腺癌细胞系具有持续细胞毒性作用。

Abemaciclib-loaded ethylcellulose based nanosponges for sustained cytotoxicity against MCF-7 and MDA-MB-231 human breast cancer cells lines.

作者信息

Anwer Md Khalid, Fatima Farhat, Ahmed Mohammed Muqtader, Aldawsari Mohammed F, Alali Amer S, Kalam Mohd Abul, Alshamsan Aws, Alkholief Musaed, Malik Abdul, Az Alanazi, Al-Shdefat Ramadan

机构信息

Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

出版信息

Saudi Pharm J. 2022 Jun;30(6):726-734. doi: 10.1016/j.jsps.2022.03.019. Epub 2022 Apr 6.

DOI:10.1016/j.jsps.2022.03.019
PMID:35812154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9257851/
Abstract

Abemaciclib (AC) is a novel, orally available drug molecule approved for the treatment of breast cancer. Due to its low bioavailability, its administration frequency is two to three times a day that can decrease patient compliance. Sustained release formulation are needed for prolong the action and to reduce the adverse effects. The aim of current study was to develop sustained release NSs of AC. Nanosponges (NSs) was prepared by emulsion-solvent diffusion method using ethyl-cellulose (EC) and Kolliphor P-188 (KP-188) as sustained-release polymer and surfactant, respectively. Effects of varying surfactant concentration and drug: polymer proportions on the particle size (PS), polydispersity index (PDI), zeta potential (ζP), entrapment efficiency (%EE), and drug loading (%DL) were investigated. The results of AC loaded NSs (ACN1-ACN5) exhibited PS (366.3-842.2 nm), PDI (0.448-0.853), ζP (-8.21 to -19.7 mV), %EE (48.45-79.36%) and %DL (7.69-19.17%), respectively. Moreover, ACN2 showed sustained release of Abemaciclib (77.12 ± 2.54%) in 24 h Higuchi matrix as best fit kinetics model. MTT assay signified ACN2 as potentials cytotoxic nanocarrier against MCF-7 and MDA-MB-231 human breast cancer cells. Further, ACN2 displayed drug release property without variation in the % release after exposing the product at 25 °C, 5 °C, and 45 °C storage conditions for six months. This investigation proved that the developed NSs would be an efficient carrier to sustain the release of AC in order to improve efficacy against breast cancer.

摘要

阿贝西利（AC）是一种新型的口服可用药物分子，已被批准用于治疗乳腺癌。由于其生物利用度低，给药频率为每天两到三次，这可能会降低患者的依从性。需要缓释制剂来延长作用时间并减少不良反应。本研究的目的是开发阿贝西利的缓释纳米海绵（NSs）。采用乙基纤维素（EC）和聚氧乙烯蓖麻油（KP - 188）分别作为缓释聚合物和表面活性剂，通过乳液 - 溶剂扩散法制备纳米海绵。研究了不同表面活性剂浓度和药物与聚合物比例对粒径（PS）、多分散指数（PDI）、zeta电位（ζP）、包封率（%EE）和载药量（%DL）的影响。载阿贝西利的纳米海绵（ACN1 - ACN5）的结果分别显示PS为（366.3 - 842.2nm）、PDI为（0.448 - 0.853）、ζP为（ - 8.21至 - 19.7mV）、%EE为（48.45 - 79.36%）和%DL为（7.69 - 19.17%）。此外，ACN2在24小时的Higuchi基质中显示阿贝西利的缓释（77.12 ± 2.54%），为最佳拟合动力学模型。MTT试验表明ACN2作为针对MCF - 7和MDA - MB - 231人乳腺癌细胞的潜在细胞毒性纳米载体。此外，将产品在25°C、5°C和45°C储存条件下放置六个月后，ACN2显示出药物释放特性，且%释放率无变化。该研究证明，所开发的纳米海绵将是一种有效的载体，可维持阿贝西利的释放，以提高对乳腺癌的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/3ca0b4595b29/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/4f38f840fc54/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6af78614ca9f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6f3f378cddf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6b4f3cd3d208/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/7f837f80695e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/50cd1dc31218/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/1f651fbcbad1/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/3ca0b4595b29/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/4f38f840fc54/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6af78614ca9f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6f3f378cddf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/6b4f3cd3d208/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/7f837f80695e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/50cd1dc31218/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/1f651fbcbad1/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7771/9257851/3ca0b4595b29/gr8.jpg

相似文献

1
Abemaciclib-loaded ethylcellulose based nanosponges for sustained cytotoxicity against MCF-7 and MDA-MB-231 human breast cancer cells lines.负载阿贝西利的乙基纤维素基纳米海绵对MCF-7和MDA-MB-231人乳腺癌细胞系具有持续细胞毒性作用。
Saudi Pharm J. 2022 Jun;30(6):726-734. doi: 10.1016/j.jsps.2022.03.019. Epub 2022 Apr 6.
2
Design of Olmesartan Medoxomil-Loaded Nanosponges for Hypertension and Lung Cancer Treatments.用于高血压和肺癌治疗的奥美沙坦酯纳米海绵的设计
Polymers (Basel). 2021 Jul 11;13(14):2272. doi: 10.3390/polym13142272.
3
Formulation and evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection.含布替萘芬的局部用纳米海绵基凝胶治疗真菌性皮肤感染的制剂与评价
Saudi Pharm J. 2021 May;29(5):467-477. doi: 10.1016/j.jsps.2021.04.010. Epub 2021 Apr 27.
4
Development of Diphenyl carbonate-Crosslinked Cyclodextrin Based Nanosponges for Oral Delivery of Baricitinib: Formulation, Characterization and Pharmacokinetic Studies.基于二苯碳酸酯交联环糊精的纳米海绵用于巴瑞替尼口服给药的研制：制剂、表征和药代动力学研究。
Int J Nanomedicine. 2023 Apr 27;18:2239-2251. doi: 10.2147/IJN.S405534. eCollection 2023.
5
Brigatinib loaded poly(d,l-lactide-co-glycolide) nanoparticles for improved anti-tumoral activity against non-small cell lung cancer cell lines.布立尼布载药聚（丙交酯-乙交酯）纳米粒提高非小细胞肺癌细胞系的抗肿瘤活性。
Drug Dev Ind Pharm. 2021 Jul;47(7):1112-1120. doi: 10.1080/03639045.2021.1983585. Epub 2021 Oct 1.
6
Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy.用于乳腺癌治疗的载有地奥司明的碳酸二苯酯交联环糊精纳米海绵的制备与评价
Pharmaceuticals (Basel). 2022 Dec 23;16(1):19. doi: 10.3390/ph16010019.
7
Preparation, Characterization, and Pharmacological Investigation of Withaferin-A Loaded Nanosponges for Cancer Therapy; In Vitro, In Vivo and Molecular Docking Studies.载醉茄酮 A 纳米海绵的制备、表征及用于癌症治疗的药理学研究；体外、体内及分子对接研究。
Molecules. 2021 Nov 19;26(22):6990. doi: 10.3390/molecules26226990.
8
Docetaxel-loaded PLGA nanoparticles to increase pharmacological sensitivity in MDA-MB-231 and MCF-7 breast cancer cells.负载多西他赛的聚乳酸-羟基乙酸共聚物纳米粒可提高MDA-MB-231和MCF-7乳腺癌细胞的药理敏感性。
Korean J Physiol Pharmacol. 2021 Sep 1;25(5):479-488. doi: 10.4196/kjpp.2021.25.5.479.
9
Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, and evaluation.盐酸特比萘芬纳米海绵的设计与优化：全因子设计的应用及评价
J Adv Pharm Technol Res. 2020 Jan-Mar;11(1):13-19. doi: 10.4103/japtr.JAPTR_85_19.
10
Formulation and Evaluation of Apigenin-Loaded Hybrid Nanoparticles.载芹菜素杂化纳米粒的制备与评价
Pharmaceutics. 2022 Apr 3;14(4):783. doi: 10.3390/pharmaceutics14040783.

引用本文的文献

1
Physicochemical Characterization, Drug Release, Stability, and Cytotoxicity of Cross-Linked Curdlan-Based Nanosponges for α-Amyrin and Higenamine Delivery.用于递送齐墩果酸和去甲乌药碱的交联基于可德兰胶的纳米海绵的物理化学表征、药物释放、稳定性和细胞毒性
Turk J Pharm Sci. 2025 Aug 1;22(3):178-190. doi: 10.4274/tjps.galenos.2025.56949.
2
Effect of palliative radiotherapy and cyclin-dependent kinase 4/6 inhibitor on breast cancer cell lines.姑息性放疗和细胞周期蛋白依赖性激酶4/6抑制剂对乳腺癌细胞系的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 4. doi: 10.1007/s00210-025-03878-6.
3
A quality-by-design approach to develop abemaciclib solid lipid nanoparticles for targeting breast cancer cell lines.

本文引用的文献

1
Formulation and characterization of tobramycin-chitosan nanoparticles coated with zinc oxide nanoparticles.包覆氧化锌纳米颗粒的妥布霉素-壳聚糖纳米颗粒的制备与表征
Saudi Pharm J. 2022 Apr;30(4):454-461. doi: 10.1016/j.jsps.2022.01.016. Epub 2022 Jan 31.
2
Design of Olmesartan Medoxomil-Loaded Nanosponges for Hypertension and Lung Cancer Treatments.用于高血压和肺癌治疗的奥美沙坦酯纳米海绵的设计
Polymers (Basel). 2021 Jul 11;13(14):2272. doi: 10.3390/polym13142272.
3
Selective targeting of cancer signaling pathways with nanomedicines: challenges and progress.
采用质量源于设计的方法开发用于靶向乳腺癌细胞系的阿贝西利固体脂质纳米粒。
Ther Deliv. 2025 Feb;16(2):123-137. doi: 10.1080/20415990.2025.2457314. Epub 2025 Jan 29.
4
Novel indolyl 1,2,4-triazole derivatives as potential anti-proliferative agents: studies, synthesis, and biological evaluation.新型吲哚基1,2,4-三唑衍生物作为潜在的抗增殖剂：研究、合成及生物学评价
RSC Med Chem. 2023 Nov 24;15(1):293-308. doi: 10.1039/d3md00524k. eCollection 2024 Jan 25.
5
Nanosponge: A promising and intriguing strategy in medical and pharmaceutical Science.纳米海绵：医学和制药科学中一种有前景且引人入胜的策略。
Heliyon. 2023 Dec 6;10(1):e23303. doi: 10.1016/j.heliyon.2023.e23303. eCollection 2024 Jan 15.
6
Methanol extract of Iraqi Kurdistan Region as a potent source of antioxidant, antimicrobial, and anticancer agents for the synthesis of novel and bioactive polyvinylpyrrolidone nanofibers.伊拉克库尔德斯坦地区的甲醇提取物，作为一种强大的抗氧化剂、抗菌剂和抗癌剂来源，用于合成新型生物活性聚乙烯吡咯烷酮纳米纤维。
Front Chem. 2023 Oct 25;11:1287870. doi: 10.3389/fchem.2023.1287870. eCollection 2023.
7
Ribociclib Hybrid Lipid-Polymer Nanoparticle Preparation and Characterization for Cancer Treatment.用于癌症治疗的瑞博西尼脂质-聚合物混合纳米粒的制备与表征
Polymers (Basel). 2023 Jun 28;15(13):2844. doi: 10.3390/polym15132844.
8
Current advances in nanodrug delivery systems for malaria prevention and treatment.用于疟疾预防和治疗的纳米药物递送系统的当前进展。
Discov Nano. 2023 Apr 20;18(1):66. doi: 10.1186/s11671-023-03849-x.
9
Targeted Fisetin-Encapsulated β-Cyclodextrin Nanosponges for Breast Cancer.用于乳腺癌治疗的靶向载有漆黄素的β-环糊精纳米海绵
Pharmaceutics. 2023 May 12;15(5):1480. doi: 10.3390/pharmaceutics15051480.
10
Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy.用于乳腺癌治疗的载有地奥司明的碳酸二苯酯交联环糊精纳米海绵的制备与评价
Pharmaceuticals (Basel). 2022 Dec 23;16(1):19. doi: 10.3390/ph16010019.
纳米医学靶向癌症信号通路：挑战与进展。
Future Oncol. 2020 Dec;16(35):2959-2979. doi: 10.2217/fon-2020-0198. Epub 2020 Aug 17.
4
Formulation Design, Statistical Optimization, and In Vitro Evaluation of a Naringenin Nanoemulsion to Enhance Apoptotic Activity in A549 Lung Cancer Cells.用于增强A549肺癌细胞凋亡活性的柚皮素纳米乳剂的处方设计、统计优化及体外评价
Pharmaceuticals (Basel). 2020 Jul 15;13(7):152. doi: 10.3390/ph13070152.
5
Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis.用于药物递送、成像和诊疗一体化的刺激响应性聚合物纳米载体
Polymers (Basel). 2020 Jun 22;12(6):1397. doi: 10.3390/polym12061397.
6
Molecular insights and novel approaches for targeting tumor metastasis.肿瘤转移的分子见解和新方法。
Int J Pharm. 2020 Jul 30;585:119556. doi: 10.1016/j.ijpharm.2020.119556. Epub 2020 Jun 20.
7
Drug repurposing for breast cancer therapy: Old weapon for new battle.药物重用于乳腺癌治疗：旧武器用于新战斗。
Semin Cancer Biol. 2021 Jan;68:8-20. doi: 10.1016/j.semcancer.2019.09.012. Epub 2019 Sep 21.
8
Preparation and characterization of insulin chitosan-nanoparticles loaded in buccal films.制备并表征壳聚糖-胰岛素纳米粒子负载的口腔黏膜片。
Pharm Dev Technol. 2019 Oct;24(8):967-974. doi: 10.1080/10837450.2019.1619183. Epub 2019 Jun 4.
9
Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats.载阿普司特聚乳酸-羟基乙酸共聚物纳米粒的制备及其在大鼠体内的药代动力学研究。
Int J Nanomedicine. 2019 Mar 1;14:1587-1595. doi: 10.2147/IJN.S195048. eCollection 2019.
10
A paradigm shift for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer: a review of CDK inhibitors.激素受体阳性、人表皮生长因子受体2阴性（HR+/HER2-）晚期乳腺癌治疗的范式转变：细胞周期蛋白依赖性激酶（CDK）抑制剂综述
Drugs Context. 2018 Nov 5;7:212555. doi: 10.7573/dic.212555. eCollection 2018.