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坦索罗辛诱发的心房颤动伴快速心室反应。

Tamsulosin-Induced Atrial Fibrillation With Rapid Ventricular Response.

作者信息

McGuire Duncan, Ahdi Heaveen, Mielke Nicholas, Bahl Amit

机构信息

Emergency Medicine, Beaumont Health, Royal Oak, USA.

Emergency, Oakland University William Beaumont School of Medicine, Royal Oak, USA.

出版信息

Cureus. 2022 Jun 7;14(6):e25714. doi: 10.7759/cureus.25714. eCollection 2022 Jun.

DOI:10.7759/cureus.25714
PMID:35812583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9261835/
Abstract

Tamsulosin, sold under the brand name Flomax, is a commonly prescribed medication for benign prostatic hypertrophy (BPH). While generally well-tolerated, this medication can induce life-threatening tachyarrhythmias. Early recognition of this adverse effect can lead to prompt discontinuation of the therapy in an effort to reduce arrhythmia recurrence. Herein we describe a case of atrial fibrillation with rapid ventricular response in a male patient who started on tamsulosin two days prior.

摘要

坦索罗辛，以商品名“哈乐”销售，是一种常用于治疗良性前列腺增生（BPH）的药物。虽然一般耐受性良好，但这种药物可诱发危及生命的快速性心律失常。早期识别这种不良反应可促使及时停药，以减少心律失常的复发。在此，我们描述一例男性患者，在开始服用坦索罗辛两天后出现伴有快速心室反应的心房颤动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/ddb7edb830e6/cureus-0014-00000025714-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/4ad78cfe5408/cureus-0014-00000025714-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/faf717be5447/cureus-0014-00000025714-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/ddb7edb830e6/cureus-0014-00000025714-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/4ad78cfe5408/cureus-0014-00000025714-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/faf717be5447/cureus-0014-00000025714-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a137/9261835/ddb7edb830e6/cureus-0014-00000025714-i03.jpg

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本文引用的文献

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Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association.药物性心律失常：美国心脏协会的科学声明。
Circulation. 2020 Oct 13;142(15):e214-e233. doi: 10.1161/CIR.0000000000000905. Epub 2020 Sep 15.
2
Initial Precipitants and Recurrence of Atrial Fibrillation.初始诱发因素与心房颤动的复发。
Circ Arrhythm Electrophysiol. 2020 Mar;13(3):e007716. doi: 10.1161/CIRCEP.119.007716. Epub 2020 Feb 12.
3
Combination therapy with solifenacin and tamsulosin oral controlled absorption system in a single tablet for lower urinary tract symptoms in men: efficacy and safety results from the randomised controlled NEPTUNE trial.
索利那新与坦索罗辛口服控释系统单片制剂治疗男性下尿路症状的联合治疗：来自随机对照 NEPTUNE 试验的疗效和安全性结果。
Eur Urol. 2013 Dec;64(6):1003-12. doi: 10.1016/j.eururo.2013.07.034. Epub 2013 Aug 3.
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Atrial fibrillation: profile and burden of an evolving epidemic in the 21st century.心房颤动：21 世纪不断演变的流行疾病特征与负担。
Int J Cardiol. 2013 Sep 1;167(5):1807-24. doi: 10.1016/j.ijcard.2012.12.093. Epub 2013 Feb 4.
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Risk factors for atrial fibrillation recurrence: a literature review.心房颤动复发的危险因素：文献综述。
J Cardiovasc Med (Hagerstown). 2014 Mar;15(3):235-53. doi: 10.2459/JCM.0b013e328358554b.
6
Is pursuit of termination of atrial fibrillation during catheter ablation of great value in patients with longstanding persistent atrial fibrillation?对于持续性心房颤动病史较长的患者，在行导管消融术时是否应积极追求终止心房颤动？
J Cardiovasc Electrophysiol. 2012 Oct;23(10):1051-8. doi: 10.1111/j.1540-8167.2012.02370.x. Epub 2012 Aug 7.
7
Is discharge to home after emergency department cardioversion safe for the treatment of recent-onset atrial fibrillation?急诊行电复律转复后的出院治疗对于新发心房颤动安全吗？
Ann Emerg Med. 2011 Dec;58(6):517-20. doi: 10.1016/j.annemergmed.2011.06.014. Epub 2011 Jul 29.
8
Tamsulosin oral controlled absorption system (OCAS) in the treatment of benign prostatic hypertrophy.坦索罗辛口服控释系统（OCAS）治疗良性前列腺增生。
Ther Clin Risk Manag. 2008 Feb;4(1):11-8. doi: 10.2147/tcrm.s86.
9
Urologic diseases in America project: benign prostatic hyperplasia.美国泌尿系统疾病项目：良性前列腺增生
J Urol. 2005 Apr;173(4):1256-61. doi: 10.1097/01.ju.0000155709.37840.fe.
10
Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms.坦索罗辛：其药理学及治疗下尿路症状疗效的综述
Drugs Aging. 2002;19(2):135-61. doi: 10.2165/00002512-200219020-00004.