Panara Kalpesh, Nariya Mukeshkumar, Karra Nishteswar
Department of Dravyaguna, Institute of Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
Pharmacology Laboratory, Institute of Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
Ayu. 2020 Oct-Dec;41(4):250-254. doi: 10.4103/ayu.AYU_251_20. Epub 2022 Jun 3.
Sleep disorders have a comparatively high prevalence worldwide and create a burden on the health system. Pharmacological agents used for insomnia are associated with considerable side effects. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy effort. ( DC.) rhizome has been recommended for insomnia and mental conditions in the Indian system of medicine.
This study aimed to determine central nervous system (CNS) depressant activity of (. rhizome on experimental animals.
Gross behavior study and open field test (locomotor activity) were performed by using Charle's foster albino rats whereas rota-rod test and pentobarbital-induced sleep test in mice. Animals were divided into 3 groups (per model) having six animals in each group. The control group was treated with water, the standard group with diazepam and the test drug with powder of . rhizome. Results were calculated by one-way ANOVA and test with < 0.05 as significant.
Data suggested that did not produce a significant effect on the behavior of animals. It reduced the horizontal activity significantly ( < 0.001) in the open field apparatus. The test drug did not show a significant decrease in latency of fall-off time in rota-rod performance in mice. Still, it exerted a significant effect by a reduction in latency of onset of sleep ( < 0.01) and also extended the total duration of sleep ( < 0.05) in albino mice in comparison to the control group.
This study shows that rhizome powder possesses CNS depressant activity without affecting gross behavior and muscle coordination in rats.
睡眠障碍在全球范围内具有较高的患病率，并给卫生系统带来负担。用于失眠的药物具有相当多的副作用。因此，从植物性天然来源寻找安全有效的药物是一项值得努力的工作。在印度医学体系中，（某植物）根茎已被推荐用于治疗失眠和精神疾病。
本研究旨在确定（某植物）根茎对实验动物的中枢神经系统（CNS）抑制活性。
使用查尔斯福斯特白化大鼠进行总体行为研究和旷场试验（运动活性），而在小鼠中进行转棒试验和戊巴比妥诱导的睡眠试验。动物分为3组（每个模型），每组6只动物。对照组用水处理，标准组用地西泮处理，试验药物用（某植物）根茎粉末处理。结果通过单因素方差分析计算，P<0.05为有显著性差异。
数据表明（某植物）对动物行为没有产生显著影响。它在旷场装置中显著降低了水平活动（P<0.001）。试验药物在小鼠转棒试验中未显示出跌落时间潜伏期的显著降低。然而，与对照组相比，它对白化病小鼠的入睡潜伏期有显著影响（P<0.01），并且还延长了总睡眠时间（P<0.05）。
本研究表明（某植物）根茎粉末具有中枢神经系统抑制活性，且不影响大鼠的总体行为和肌肉协调性。
