Guzman Aparicio Maria A, Liebman Daniel L, Chodosh James, Freitag Suzanne K, Kazlas Melanie, Mai Derek D, Marando Catherine M, Mukai Shizuo, Wu Annie M, Chen Teresa C
Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
Massachusetts Eye and Ear, Glaucoma Service, Boston, MA, USA.
Am J Ophthalmol Case Rep. 2022 Jun 28;27:101638. doi: 10.1016/j.ajoc.2022.101638. eCollection 2022 Sep.
To report two pediatric cases of reticular corneal epithelial edema associated with the use of netarsudil ophthalmic solution 0.02%.
In Case 1, a six-year-old male with glaucoma following cataract surgery was treated with netarsudil for thirteen months and developed diffuse reticular corneal epithelial edema on post-operative day one after undergoing transscleral diode cyclophotocoagulation for persistently elevated intraocular pressures. In Case 2, a three-month-old male with bilateral ocular hypertension developed unilateral inferior reticular corneal epithelial edema five weeks after initiation of netarsudil, which had been discontinued in the fellow eye two weeks prior. In both cases, the reticular epithelial edema resolved following cessation of netarsudil.
Netarsudil-associated reticular corneal epithelial edema can occur in infants and young children.
报告两例与使用0.02%奈他地尔滴眼液相关的小儿网状角膜上皮水肿病例。
病例1中，一名白内障手术后患青光眼的6岁男性接受奈他地尔治疗13个月，在因持续高眼压接受经巩膜二极管睫状体光凝术后第一天出现弥漫性网状角膜上皮水肿。病例2中，一名3个月大的双侧高眼压男性在开始使用奈他地尔5周后出现单侧下方网状角膜上皮水肿，对侧眼两周前已停用该药。两例病例中，停用奈他地尔后网状上皮水肿均消退。
奈他地尔相关的网状角膜上皮水肿可发生于婴幼儿。
