Cornea and External Disease Division, Refractive Surgery Service, Duke University Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
Cornea and External Disease Division, Refractive Surgery Service, Duke University Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
Am J Ophthalmol. 2020 Sep;217:20-26. doi: 10.1016/j.ajo.2020.04.002. Epub 2020 Apr 11.
To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil.
Retrospective case series.
Case series at a single academic center where treatment with netarsudil produced a particular pattern of bullous epithelial corneal edema.
Six episodes of reticular bullous epithelial corneal edema were identified in 5 eyes of 5 patients treated with netarsudil. A total of 4 of 5 patients had a history of corneal edema in the affected eye, and the fifth patient had risk factors for corneal edema including a history of anterior uveitis and an anterior chamber glaucoma drainage device. In 4 of 6 episodes, corneal edema was present, typically in the corneal stroma at the time of netarsudil initiation. In 5 of 6 cases, visual acuity worsened with onset of bullous epithelial edema, and in all cases, visual acuity stabilized or improved following discontinuation of netarsudil. In all cases, the reticular bullous epithelial edema improved or resolved after discontinuation of netarsudil.
The patient characteristics and natural history of a particular pattern of reticular bullous epithelial edema in a series of patients treated with netarsudil once daily is reported. Most patients had a history of corneal edema or predisposing risk factors for corneal edema. All patients demonstrated improvement in bullous epithelial edema after netarsudil discontinuation. Visual acuity improved in most patients within weeks after discontinuation of netarsudil, although 2 patients also underwent surgical interventions that might have contributed to improved visual acuity.
描述一系列接受 netarsudil 治疗的患者中出现的非典型网状大疱性上皮性角膜水肿的患者特征和临床病程。
回顾性病例系列。
在一家学术中心进行的病例系列研究，在该中心，netarsudil 的治疗产生了一种特殊的大疱性上皮性角膜水肿模式。
在 5 名接受 netarsudil 治疗的患者的 5 只眼中，共发现了 6 次网状大疱性上皮性角膜水肿。共有 4 例患者的受影响眼中存在角膜水肿史，第 5 例患者存在角膜水肿的危险因素，包括前葡萄膜炎史和前房青光眼引流装置。在 6 次发作中的 4 次中，角膜水肿在开始使用 netarsudil 时通常存在于角膜基质中。在 5 例中的 6 例中，大疱性上皮水肿出现时视力下降，在所有病例中，停药后视力稳定或改善。在所有病例中，网状大疱性上皮水肿在停用 netarsudil 后均改善或消退。
报道了一系列接受 netarsudil 每日一次治疗的患者中出现的一种特殊的网状大疱性上皮水肿的患者特征和自然病程。大多数患者有角膜水肿史或角膜水肿的易患危险因素。所有患者在停用 netarsudil 后，大疱性上皮水肿均得到改善。大多数患者在停用 netarsudil 后数周内视力提高，尽管 2 例患者还接受了手术干预，这可能有助于提高视力。
