Jiangsu Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2022 Jun 23;13:875425. doi: 10.3389/fendo.2022.875425. eCollection 2022.
Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in sustaining volume and hemodynamics homeostasis. PGE2 works through four distinct E-prostanoid (EP) receptors which are G protein-coupled receptors. To date, pharmacological specific antagonists and agonists of all four subtypes of EP receptors and genetic targeting knockout mice for each subtype have helped in uncoupling the diverse functions of PGE2 and discriminating the respective characteristics of each receptor. In this review, we summarized the functions of individual EP receptor subtypes in the renal and blood vessels and the molecular mechanism of PGE2-induced fluid metabolism and blood pressure homeostasis.
前列腺素 E2（PGE2）是一种在肾脏和心血管系统中广泛表达的重要前列腺素。尽管 PGE2 对液体代谢和血压有多种影响，但它与维持容量和血液动力学平衡有关。PGE2 通过四个不同的 E 前列腺素（EP）受体发挥作用，这些受体都是 G 蛋白偶联受体。迄今为止，所有四种 EP 受体亚型的药理学特异性拮抗剂和激动剂以及针对每种亚型的基因靶向敲除小鼠，都有助于分离 PGE2 的多种功能，并区分每个受体的各自特征。在这篇综述中，我们总结了 EP 受体亚型在肾脏和血管中的功能以及 PGE2 诱导的液体代谢和血压平衡的分子机制。
