中枢和外周前列腺素 E2 及其 EP 亚型在血压调节中的不同作用。
Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation.
机构信息
Institute of Hypertension, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China.
出版信息
Am J Hypertens. 2012 Oct;25(10):1042-9. doi: 10.1038/ajh.2012.67. Epub 2012 Jun 14.
Abstract
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.
摘要
前列腺素 E(2)（PGE(2)）是一种具有广泛生物活性的主要前列腺素。PGE(2)可以对血压（BP）产生正反两方面的影响。具体来说，中枢给予 PGE(2)会引起高血压，而全身给予 PGE(2)则会产生降压作用。这些生理上相反的作用是由多种 EP 受体的存在产生的，即 EP(1-4)，它们是具有不同信号转导特性的 G 蛋白偶联受体。本综述强调了 PGE(2)在血压调节中的独特作用以及特定 EP 受体亚型的参与。
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