前列腺素与心血管疾病的关系。

Computational Genomics Lab, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.

aDNA Lab, Department of Cultural Heritage, University of Bologna, Ravenna Campus, 48121 Ravenna, Italy.

Int J Mol Sci. 2023 Feb 20;24(4):4193. doi: 10.3390/ijms24044193.

Cardiovascular diseases are the leading cause of global deaths, and many risk factors contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic acid, have attracted attention for their involvement in cardiovascular homeostasis and inflammatory processes. Prostanoids are the target of several drugs, but it has been shown that some of them increase the risk of thrombosis. Overall, many studies have shown that prostanoids are tightly associated with cardiovascular diseases and that several polymorphisms in genes involved in their synthesis and function increase the risk of developing these pathologies. In this review, we focus on molecular mechanisms linking prostanoids to cardiovascular diseases and we provide an overview of genetic polymorphisms that increase the risk for cardiovascular disease.

心血管疾病是全球死亡的主要原因，许多风险因素导致其发病机制。在这种情况下，前列腺素类物质，源自花生四烯酸，因其参与心血管稳态和炎症过程而受到关注。前列腺素类物质是几种药物的作用靶点，但已经表明其中一些会增加血栓形成的风险。总的来说，许多研究表明前列腺素类物质与心血管疾病密切相关，并且涉及它们合成和功能的几个基因中的遗传多态性增加了发生这些病理的风险。在这篇综述中，我们重点介绍将前列腺素类物质与心血管疾病联系起来的分子机制，并概述增加心血管疾病风险的遗传多态性。