Department of Human Reproduction, Division of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Faculty of Sports, University of Ljubljana, Ljubljana, Slovenia.
Front Endocrinol (Lausanne). 2022 Jun 22;13:888460. doi: 10.3389/fendo.2022.888460. eCollection 2022.
Polycystic ovary syndrome (PCOS) is a polyendocrine disorder and the most common endocrinopathy in women of reproductive age. Affected women have an elevated prevalence of being overweight and obese. Our study sought to determine how weight loss associated with lifestyle changes affects the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. A group of 12 infertile women under the age of 38 with PCOS and BMI ≥30 kg/m were included in the study. An evaluation was performed by a gynecologist and an endocrinologist. The weight-loss program lasted 8 weeks under the guidance of a professional trainer. Endometrial sampling during a period of implantation window for proteome determination was performed before and after weight loss. In endometrial samples at the end of the study increased protein abundance was recorded for Legumain, Insulin-like growth factor-binding protein 7, Hepatocyte growth factor receptor, Keratin, type II cytoskeletal 7, and Cystatin-B, while the B-lymphocyte antigen CD20 protein abundance decreased. Our results also indicate significantly lowered fasting blood glucose level and free testosterone concentration and significant improvements in body composition and physical capacity. This study may open up the venues for investigating important biomarkers that may affect endometrial receptivity.
https://clinicaltrials.gov/ct2/show/NCT04989244?term=NCT04989244&draw=2&rank=1, identifier: NCT04989244.
多囊卵巢综合征（PCOS）是一种多内分泌疾病，也是育龄妇女中最常见的内分泌疾病。受影响的女性超重和肥胖的患病率较高。我们的研究旨在确定与生活方式改变相关的体重减轻如何影响肥胖多囊卵巢综合征和不孕妇女的子宫内膜特异性蛋白质组、内分泌代谢特征和运动能力。本研究纳入了 12 名年龄在 38 岁以下、BMI≥30kg/m2 的不孕多囊卵巢综合征妇女。由妇科医生和内分泌学家进行评估。在专业教练的指导下，进行为期 8 周的减肥计划。在减肥前后的着床窗口期间进行子宫内膜取样，用于蛋白质组测定。在研究结束时的子宫内膜样本中，记录到 Legumain、胰岛素样生长因子结合蛋白 7、肝细胞生长因子受体、角蛋白、II 型细胞骨架 7 和胱抑素-B 的蛋白丰度增加，而 B 淋巴细胞抗原 CD20 的蛋白丰度降低。我们的结果还表明空腹血糖水平和游离睾酮浓度显著降低，身体成分和身体能力显著改善。这项研究可能为研究可能影响子宫内膜容受性的重要生物标志物开辟途径。
https://clinicaltrials.gov/ct2/show/NCT04989244?term=NCT04989244&draw=2&rank=1，标识符：NCT04989244。
