Morris Darcy, Gonzalez Raquel, Cook Jane, Metts Jonathan, Shaw Peter
Office of Medical Education, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Division of Pediatric Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Case Rep Oncol. 2022 May 12;15(2):515-521. doi: 10.1159/000522441. eCollection 2022 May-Aug.
A 15-year-old male with a mesenteric desmoid tumor and underlying familial adenomatous polyposis presented 2 weeks after initiating sorafenib with severe abdominal pain and chills and was found to have an acute abdomen. Exploratory laparotomy revealed a necrotic, ruptured tumor with impending small bowel obstruction. The patient was later able to resume sorafenib and experienced sustained a radiographic response. It is possible that sorafenib toxicity contributed to tumor rupture yet later provided clinical benefit. Here we review the gastrointestinal complications that are associated with intra-abdominal desmoid tumors and their therapies.
一名15岁男性，患有肠系膜硬纤维瘤及潜在的家族性腺瘤性息肉病，在开始使用索拉非尼2周后出现严重腹痛和寒战，被发现患有急腹症。剖腹探查发现一个坏死、破裂的肿瘤，伴有即将发生的小肠梗阻。该患者后来能够恢复使用索拉非尼，并经历了持续的影像学反应。索拉非尼毒性可能导致了肿瘤破裂，但后来却带来了临床益处。在此，我们回顾与腹腔内硬纤维瘤相关的胃肠道并发症及其治疗方法。
