Dong Yuling, Ding Zhongfeng, Song Linxia, Zhang Desheng, Xie Changjian, Zhang Shujing, Feng Ling, Liu Hongliang, Pang Qiuxiang
Institute for Anti-aging and Regenerative Medicine Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, China.
Front Microbiol. 2022 Jun 22;13:911928. doi: 10.3389/fmicb.2022.911928. eCollection 2022.
Sodium benzoate (SB), the sodium salt of benzoic acid, is widely used as a preservative in foods and drinks. The toxicity of SB to the human body attracted people's attention due to the excessive use of preservatives and the increased consumption of processed and fast foods in modern society. The SB can inhibit the growth of bacteria, fungi, and yeast. However, less is known of the effect of SB on host commensal microbial community compositions and their functions. In this study, we investigated the effect of SB on the growth and development of larvae and whether SB affects the commensal microbial compositions and functions. We also attempted to clarify the interaction between SB, commensal microbiota and host development by detecting the response of commensal microbiota after the intervention. The results show that SB significantly retarded the development of larvae, shortened the life span, and changed the commensal microbial community. In addition, SB changed the transcription level of endocrine coding genes such as and . These results indicate that the slow down in larvae developmental timing and shortened life span of adult flies caused by SB intake may result from the changes in endocrine hormone levels and commensal microbiota. This study provided experimental data that indicate SB could affect host growth and development of through altering endocrine hormone levels and commensal microbial composition.
苯甲酸钠（SB）是苯甲酸的钠盐，在食品和饮料中广泛用作防腐剂。由于现代社会中防腐剂的过度使用以及加工食品和快餐消费的增加，SB对人体的毒性引起了人们的关注。SB可以抑制细菌、真菌和酵母的生长。然而，关于SB对宿主共生微生物群落组成及其功能的影响知之甚少。在本研究中，我们调查了SB对幼虫生长发育的影响以及SB是否影响共生微生物组成和功能。我们还试图通过检测干预后共生微生物群的反应来阐明SB、共生微生物群与宿主发育之间的相互作用。结果表明，SB显著延缓了幼虫的发育，缩短了寿命，并改变了共生微生物群落。此外，SB改变了诸如[具体基因1]和[具体基因2]等内分泌编码基因的转录水平。这些结果表明，摄入SB导致幼虫发育时间减慢和成年果蝇寿命缩短可能是由于内分泌激素水平和共生微生物群的变化。本研究提供了实验数据，表明SB可通过改变内分泌激素水平和共生微生物组成来影响宿主的生长发育。
