Zong Yao, Gao Qian-Ying, Hui Yan-Nian
Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China.
Vesber Vitreous Institute, Guanghzou 510000, Guangdong Province, China.
Int J Ophthalmol. 2022 Jun 18;15(6):857-867. doi: 10.18240/ijo.2022.06.02. eCollection 2022.
The vitreous body, the largest intraocular component, plays a key role in eye development, refraction, cell barrier function, oxygen metabolism and the pathogenesis of assorted diseases. Age, refraction and systemic diseases can cause vitreous metabolic abnormalities. With the continuous development of vitrectomy techniques and equipment, vitreous injections and vitrectomies have increased over the recent decades. However, the normal oxygen tension gradient in the vitreous helps to protect the lens and anterior chamber angle from oxidative stress damage, whereas the increased vitreous oxygen tension around lens and the trabecular meshwork after vitrectomy. It may lead to postoperative nuclear cataract and increase the risk for glaucoma. As a conventional procedure, scleral buckling holds several advantages over vitrectomy in selected cases. This review raises concerns regarding the function of the vitreous and encourages conducting vitreous interventions prudently if it is possible.
玻璃体是眼内最大的组成部分，在眼球发育、屈光、细胞屏障功能、氧代谢及多种疾病的发病机制中起关键作用。年龄、屈光状态及全身疾病可导致玻璃体代谢异常。随着玻璃体切割技术和设备的不断发展，近几十年来玻璃体注射和玻璃体切割手术有所增加。然而，玻璃体中正常的氧张力梯度有助于保护晶状体和前房角免受氧化应激损伤，而玻璃体切割术后晶状体和小梁网周围的玻璃体氧张力增加。这可能导致术后核性白内障并增加青光眼风险。作为一种传统手术，在某些特定情况下，巩膜扣带术比玻璃体切割术具有若干优势。本综述引发了对玻璃体功能的关注，并鼓励在可能的情况下谨慎进行玻璃体干预。
