Li Chong, Sun Mingyu, Tian Shiliu
School of Kinesiology, Shanghai University of Sport, Shanghai, China.
Key Laboratory of Exercise and Health Science of Ministry of Education, Shanghai University of Sport, Shanghai, China.
Front Hum Neurosci. 2022 Jun 21;16:887246. doi: 10.3389/fnhum.2022.887246. eCollection 2022.
Transcranial magnetic stimulation, as a relatively new type of treatment, is a safe and non-invasive method for pain therapy. Here, we used CiteSpace software to visually analyze 440 studies concerning transcranial magnetic stimulation in pain research from 2010 to 2021, indexed by Web of Science, to clarify the research hotspots in different periods and characterize the process of discovery in this field. The United States ranked first in this field. Lefaucheur JP, Fregni F, and Andrade ACD made great contributions to this field of study. The most prolific institution was University of São Paulo. The four main hot keywords were neuropathic pain, motor cortex, connectivity, and non-invasive brain stimulation. There were three main points that were generally accepted: (1) definite analgesic effect of high-frequency rTMS of M1 contralateral to pain side in neuropathic pain; (2) there are inconclusive recommendations regarding rTMS of the dorsolateral prefrontal cortex (DLPFC) in fibromyalgia and neuropathic pain; (3) there is low-quality evidence that single doses of high-frequency rTMS of the motor cortex may have short-term effects on chronic pain. This bibliometric analysis indicated that prospective, multi-center, large-sample, randomized controlled trials are still needed to further verify the effectiveness of various transcranial magnetic stimulation parameters in pain research.
经颅磁刺激作为一种相对新型的治疗方法，是一种安全且无创的疼痛治疗手段。在此，我们使用CiteSpace软件对2010年至2021年Web of Science索引的440项关于经颅磁刺激在疼痛研究方面的研究进行可视化分析，以阐明不同时期的研究热点，并刻画该领域的发现过程。美国在该领域排名第一。勒福舒尔·让 - 皮埃尔、弗雷尼·费尔南多和安德拉德·阿西斯·达·科斯塔对该研究领域做出了巨大贡献。发文量最多的机构是圣保罗大学。四个主要热门关键词是神经性疼痛、运动皮层、连通性和无创脑刺激。有三个主要观点得到普遍认可：（1）在神经性疼痛中，对疼痛侧对侧的M1进行高频重复经颅磁刺激具有明确的镇痛效果；（2）关于在纤维肌痛和神经性疼痛中对背外侧前额叶皮层（DLPFC）进行重复经颅磁刺激，尚无定论；（3）有低质量证据表明单次剂量的运动皮层高频重复经颅磁刺激可能对慢性疼痛有短期影响。这项文献计量分析表明，仍需要进行前瞻性、多中心、大样本、随机对照试验，以进一步验证各种经颅磁刺激参数在疼痛研究中的有效性。
