Zhang Zhang, Gao An, Sun Chunyang
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Front Chem. 2022 Jun 22;10:905645. doi: 10.3389/fchem.2022.905645. eCollection 2022.
Developing bioresponsive nanocarriers with particular tumor cell targeting and on-demand payload release has remained a great challenge for combined chemo-photodynamic therapy (chemo-PDT). In this study, an intelligent nanocarrier (TAT-NP) responded to hierarchical endogenous tumor pH, and an exogenous red light was developed through a simple mixed micelle approach. The outside TAT ligand was masked to prevent an unexpected interaction in blood circulation. Following the accumulation of TAT-NP in tumor tissues, tumor acidity at pH ∼6.5 recovered its targeting ability triggering DA moiety degradation. Furthermore, the cascaded chemo-PDT was accomplished through light-stimulated nanocarrier disassembly and doxorubicin (DOX) release. Taking advantage of stability and controllability, this work provides a facile approach to designing bioresponsive nanocarriers and represents a proof-of-concept combinatorial chemo-PDT treatment.
开发具有特定肿瘤细胞靶向性和按需释放药物功能的生物响应性纳米载体，对于联合化疗-光动力疗法（chemo-PDT）而言仍然是一项巨大挑战。在本研究中，通过一种简单的混合胶束方法，制备了一种能够响应肿瘤内源性分级pH值并能响应外源性红光的智能纳米载体（TAT-NP）。外部的TAT配体被屏蔽，以防止在血液循环中发生意外相互作用。TAT-NP在肿瘤组织中积累后，pH值约为6.5的肿瘤酸性环境恢复其靶向能力，触发DA部分降解。此外，通过光刺激纳米载体的解体和阿霉素（DOX）的释放，实现了级联化疗-光动力疗法。利用稳定性和可控性，这项工作为设计生物响应性纳米载体提供了一种简便方法，并代表了一种概念验证性的联合化疗-光动力疗法治疗方案。
