Chow R K, Harrison J E, Sturtridge W, Josse R, Murray T M, Bayley A, Dornan J, Hammond T
Clin Invest Med. 1987 Mar;10(2):59-63.
The study was conducted in order to determine the effect of exercise on osteoporotic patients with a mean age of 65 years. The majority of these patients had been on sodium fluoride for at least 2 years. Thirty-eight patients were assigned to either the hospital or home group. Nineteen were in the former group, which performed the 1 hour exercise twice weekly in the Hospital. The patients in the latter group were taught the exercises and were expected to continue them at home. The exercise protocol consisted of muscle-strengthening and aerobic activities. Bone mineral mass was determined by neutron activation analysis, which measured total calcium in the trunk and pelvis. It is expressed as a calcium bone index (CaBI), with a normal range of 0.75 to 1.2. The level of physical performance was determined by calculating the maximum oxygen uptake, VO2max, attained by a graded exercise test on the treadmill. Calcium bone index and VO2max were obtained before and after the 12.5 month study. Prior to the study, the hospital and home groups had low calcium bone index values (0.68 and 0.66 respectively). Both groups showed a significant increase in calcium bone index (p less than 0.001 for the hospital group, p less than 0.01 for the home group) after the study. When compared to the home group the hospital group was found to have a significantly higher post-study calcium bone index value (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
开展这项研究是为了确定运动对平均年龄为65岁的骨质疏松症患者的影响。这些患者中的大多数已服用氟化钠至少两年。38名患者被分配到医院组或家庭组。19名患者在医院组，该组每周在医院进行两次1小时的运动。家庭组的患者学习了这些运动，并被期望在家中继续进行。运动方案包括肌肉强化和有氧运动。通过中子活化分析测定骨矿物质质量，该分析测量躯干和骨盆中的总钙含量。它以钙骨指数（CaBI）表示，正常范围为0.75至1.2。通过计算在跑步机上进行分级运动测试所达到的最大摄氧量（VO2max）来确定身体机能水平。在为期12.5个月的研究前后获取钙骨指数和VO2max。在研究之前，医院组和家庭组的钙骨指数值较低（分别为0.68和0.66）。研究后，两组的钙骨指数均显著增加（医院组p<0.001，家庭组p<0.01）。与家庭组相比，发现医院组研究后的钙骨指数值显著更高（p<0.02）。（摘要截选至250字）
