Division of Neurology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90110, Thailand.
Division of Neurology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90110, Thailand.
Seizure. 2022 Aug;100:87-94. doi: 10.1016/j.seizure.2022.06.017. Epub 2022 Jun 27.
Several screening questionnaires for obstructive sleep apnea (OSA) have been introduced. No study has compared the performance of different questionnaire in the same patients with epilepsy. Herein, we compare the performance characteristics of four common questionnaires for assessing the probability of OSA in patients with epilepsy.
This cross-sectional multicenter study was conducted among adult epilepsy patients attending neurology and general medical clinics in Thailand. Before performing full polysomnography (PSG), all participants completed the STOP-BANG, STOP-BAG, SA-SDQ, and NoSAS questionnaires. OSA was defined by apnea/ hypopnea index (AHI) criteria of AHI: ≥ 5, ≥ 15, and ≥ 30. Discriminatory ability was assessed by area under the receiver operating characteristics (ROC) curve (AUC) and likelihood ratio. To improve discriminative ability, we created 3 ranges of the score to predict lower, middle, and higher probability of OSA as defined by each diagnostic criterion.
A total 166 patients with epilepsy were included. OSA prevalence was 38%. Overall, NoSAS had higher AUC at all AHI criteria but not significantly higher than that of other scales. Using prediction cut-points for NoSAS of ≥ 4 and ≥ 8 to predict OSA defined by AHI ≥ 5, the likelihood ratios for the 3 ranges were 0.37, 2.22 and 9.81 respectively.
Among the 4 scales, the 2-cut-point NoSAS score had the highest discriminatory ability at each AHI cutoff.
已经引入了几种阻塞性睡眠呼吸暂停（OSA）的筛查问卷。尚无研究比较过同批癫痫患者使用不同问卷的表现。在此，我们比较了四种常用于评估癫痫患者 OSA 可能性的常见问卷的性能特征。
这是一项在泰国神经病学和普通医学诊所就诊的成年癫痫患者中进行的横断面多中心研究。在进行全夜多导睡眠图（PSG）之前，所有参与者都完成了 STOP-BANG、STOP-BAG、SA-SDQ 和 NoSAS 问卷。OSA 定义为呼吸暂停/低通气指数（AHI）标准为 AHI：≥5、≥15 和≥30。通过受试者工作特征（ROC）曲线下面积（AUC）和似然比评估鉴别能力。为了提高鉴别能力，我们根据每个诊断标准创建了 3 个评分范围，以预测 OSA 的低、中、高可能性。
共纳入 166 例癫痫患者。OSA 患病率为 38%。总体而言，NoSAS 在所有 AHI 标准下 AUC 更高，但与其他量表相比并无显著优势。使用 NoSAS 的预测切点≥4 和≥8 来预测 AHI≥5 的 OSA，3 个范围的似然比分别为 0.37、2.22 和 9.81。
在这 4 个量表中，2 分点 NoSAS 评分在每个 AHI 切点的鉴别能力最高。
