Privolzhsky Research Medical University, Nizhny Novgorod, Russia; Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.
Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.
J Psychiatr Res. 2022 Sep;153:141-148. doi: 10.1016/j.jpsychires.2022.07.020. Epub 2022 Jul 6.
It was reported that the levels of tetrahydrobiopterin (BH4) are reduced in schizophrenia. However, mechanisms of BH4 deficiency in schizophrenia had not been studied precisely.
the search of the association between BH4 deficiency in schizophrenia and a range of biochemical and clinical parameters for the evaluation of the possible mechanisms of BH4 loss and its role in the development of the symptoms.
93 patients with schizophrenia and 60 healthy volunteers were randomly selected and evaluated with a biochemical examination of BH4, folate, cobalamin (B12), homocysteine, C-reactive protein (CRP), reduced glutathione (GSH) levels in the blood serum.Patients underwent standardized psychopathological examination.
In patients, the levels of BH4 and folate were lower (p = 0.001 and p = 0.054, respectively), and the levels of homocysteine were higher (p = 0.012) compared to the control group. BH4 levels directly moderately correlated with folate (ρ = 0.43; p = 0.0029) and B12 levels (ρ = 0.43; p = 0.0020) and inversely moderately correlated with homocysteine levels (ρ = -0.54; p = 0.00015) in patients. Cluster analysis identified schizophrenia biotype characterized by a deficiency of BH4, folate, B12, and hyperhomocysteinemia. The clinical characteristics of this biotype were not specific. CRP and GSH were higher in patients compared to controls, but their association with serum BH4 was not confirmed.
有报道称，精神分裂症患者的四氢生物蝶呤（BH4）水平降低。然而，精神分裂症患者中 BH4 缺乏的确切机制尚未得到精确研究。
探索精神分裂症患者 BH4 缺乏与一系列生化和临床参数之间的关联，以评估 BH4 缺失的可能机制及其在症状发展中的作用。
随机选择 93 名精神分裂症患者和 60 名健康志愿者进行 BH4、叶酸、钴胺素（B12）、同型半胱氨酸、C 反应蛋白（CRP）、血清还原型谷胱甘肽（GSH）水平的生化检查。患者接受了标准化的精神病理学检查。
与对照组相比，患者的 BH4 和叶酸水平较低（p=0.001 和 p=0.054），同型半胱氨酸水平较高（p=0.012）。BH4 水平与叶酸（ρ=0.43；p=0.0029）和 B12 水平（ρ=0.43；p=0.0020）呈直接中度相关，与同型半胱氨酸水平呈负相关（ρ=-0.54；p=0.00015）。聚类分析确定了精神分裂症生物型，其特点是 BH4、叶酸、B12 缺乏和高同型半胱氨酸血症。这种生物型的临床特征没有特异性。与对照组相比，患者的 CRP 和 GSH 水平较高，但它们与血清 BH4 之间的关联尚未得到证实。
