Privolzhsky Research Medical University, Nizhny Novgorod, Russia; V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110823. doi: 10.1016/j.pnpbp.2023.110823. Epub 2023 Jul 13.
Various aspects of folate and tetrahydrobiopterin (BH4) metabolism disturbances have been detected in patients with schizophrenia.Data were obtained that disturbances in the pterins (folates and BH4) metabolism can be associated with oxidative stress and inflammation, but has not yet been confirmed in clinical studies in schizophrenia. Within the framework of this study, a correlation and factor analysis of biochemical markersof pterin metabolism, inflammation and redox imbalance in patients with schizophrenia was performed in order to test the hypothesis of the single etiopathogenetic node, including the studied biochemical processes. Methods: 125 patients with schizophrenia and 95 healthy volunteers were randomly selected and evaluated with a biochemical examination of BH4, folate, B12, homocysteine, C-reactive protein, interleukin-6, reduced glutathione levels in the blood serum; activity of superoxide dismutase and catalase - in erythrocytes; malondialdehyde - in blood plasma. All patients underwent an examination using standardized psychopathology rating scales. Spearman rank coefficient (ρ) with Benjamini-Hochberg correction was used for the correlation analysis. The principal components analysis (PCA) was used as a factor analysis. Results: Significant correlations were found within groups of pterin metabolism, inflammatory markers and redox-imbalance, and also between separate inflammation, oxidative stress and markers of pterin metabolism. The performed factor analysis made it possible to distinguish two components: 1 - pterin metabolism, 2 - oxidativeinflammatory markers. Despite the weak statistical associations and, possibly, functional relationships between pterin metabolism and oxidative/inflammation markers, each of the components has its own clinical correlates and, probably, a separate contribution to the pathology of schizophrenia.
已在精神分裂症患者中发现了叶酸和四氢生物蝶呤 (BH4) 代谢紊乱的各个方面。有数据表明，蝶呤（叶酸和 BH4）代谢紊乱可能与氧化应激和炎症有关，但尚未在精神分裂症的临床研究中得到证实。在本研究框架内，对精神分裂症患者的蝶呤代谢、炎症和氧化还原失衡的生化标志物进行了相关性和因子分析，以检验包括所研究生化过程在内的单一病因发病节点假说。
随机选择 125 名精神分裂症患者和 95 名健康志愿者，并进行 BH4、叶酸、B12、同型半胱氨酸、C 反应蛋白、白细胞介素-6、血清中还原型谷胱甘肽水平的生化检查；红细胞中超氧化物歧化酶和过氧化氢酶的活性；血浆中的丙二醛。所有患者均接受了标准化精神病学评分量表的检查。使用带有 Benjamini-Hochberg 校正的 Spearman 秩相关系数 (ρ) 进行相关性分析。使用主成分分析 (PCA) 进行因子分析。
在蝶呤代谢、炎症标志物和氧化还原失衡的组内以及单独的炎症、氧化应激和蝶呤代谢标志物之间发现了显著相关性。所进行的因子分析能够区分两个成分：1-蝶呤代谢，2-氧化应激-炎症标志物。尽管蝶呤代谢和氧化/炎症标志物之间存在较弱的统计学关联，并且可能存在功能关系，但每个成分都有其自身的临床相关性，可能对精神分裂症的发病机制有单独的贡献。
