犊牛皮肤松垂症中菜花状胶原纤维的形态计量学研究。

Morphometric study of cauliflower collagen fibrils in dermatosparaxis of the calves.

作者信息

Piérard G E, Lê T, Hermanns J F, Nusgens B V, Lapière C M

出版信息

Coll Relat Res. 1987 Feb;6(6):481-92. doi: 10.1016/s0174-173x(87)80047-x.

Abstract

The abnormal cauliflower collagen fibrils present in the skin of dermatosparactic calves were studied by electron microscopy and computerized image analysis. The structure of the fibrils is heterogeneous and varies according to their location in the dermis. Cauliflower fibrils seems due to a defect in the lateral cohesion between the constitutive procollagen polymers. This is associated with the presence of a non-collageneous material larger than the aminopropeptide surrounding the procollagen polymers, while the volume occupied by procollagen in each fibril is comparable to that of collagen in normal fibrils.

摘要

通过电子显微镜和计算机图像分析对皮肤松弛症犊牛皮肤中存在的异常菜花状胶原纤维进行了研究。这些纤维的结构是异质性的，并且根据它们在真皮中的位置而有所不同。菜花状纤维似乎是由于组成型前胶原聚合物之间横向凝聚力的缺陷所致。这与前胶原聚合物周围存在一种比氨基端前肽更大的非胶原物质有关，而每个纤维中前胶原所占的体积与正常纤维中胶原的体积相当。