用抗前胶原和I型胶原抗血清对胎儿、皮肤松垂症小牛和绵羊皮肤进行免疫组织学分析。
Immunohistologic analysis of fetal and dermatosparactic calf and sheep skin with antisera to procollagen and collagen type I.
作者信息
Wick G, Olsen B R, Timpl R
出版信息
Lab Invest. 1978 Aug;39(2):151-6.
Immunofluorescent analysis of bovine and sheep skin using antibodies to the biosynthetic precursor pn-collagen type I, demonstrated that the localization of pn-collagen is restricted to the stratum papillare in adult skin. In contrast, antibodies against pn-collagen type I stained the whole dermis in skin obtained from dermatosparactic cattle and sheep. Electron microscopy of dermatosparactic sheep skin stained with ferritin-labeled anti-pn-collagen type I antibodies further demonstrated that pn-collagen molecules are the structural components of the unusual, twisted collagen fïbers observed in dermatosparactic skin.
使用针对生物合成前体I型前胶原（pn-胶原蛋白）的抗体对牛和羊皮肤进行免疫荧光分析，结果表明，pn-胶原蛋白的定位仅限于成年皮肤的乳头层。相比之下，针对I型前胶原的抗体对皮肤松弛症牛和羊的皮肤中的整个真皮进行了染色。用铁蛋白标记的抗I型前胶原抗体对皮肤松弛症羊皮肤进行电子显微镜检查进一步表明，pn-胶原蛋白分子是在皮肤松弛症皮肤中观察到的异常扭曲胶原纤维的结构成分。
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