Department of General, Visceral and Transplantation Surgery, University Medicine of Essen Essen, Germany; Division of Transplantation, Department of Surgery, The University of Oklahoma College of Medicine, OK, USA.
Department of General, Visceral and Transplantation Surgery, University Medicine of Essen Essen, Germany.
HPB (Oxford). 2022 Nov;24(11):1975-1979. doi: 10.1016/j.hpb.2022.06.007. Epub 2022 Jun 24.
We implemented a multicenter interview with the donors to investigate Quality of Life (QoL) up to 20 years following donation.
Data were collected retrospectively. Complications were graded by Dindo-Clavien classification.
Median follow-up was 16.1 years. Out of 485 donors, 272 responded (56.1%). The majority (>90%) reported they are in excellent/good overall health and positive or no impact of donation on professional life. Length of stay (LOS) was associated with impact on professional life and return to baseline functionality (both p = 0.046). Major complication was not associated with current physical condition or return to baseline normalcy (p = 0.06). Seventy-five (27.5%) reported unsure or no to donate again. None of the parameters were associated with donation again response. Faster return to baseline functionality, and more positive impact on professional life were reported in the last decade, likely secondary to less complication rates (all p < 0.001).
This the longest follow up reports after living liver donation among German and Turkish populations. Although subject to recall bias, LOS was associated with negative impact on professional life and return to baseline functionality. Regret feelings were higher than literature. These long-term effects should be incorporated into donor discussions.
我们对供体进行了多中心访谈，以调查捐赠后 20 年的生活质量（QoL）。
数据为回顾性收集。并发症分级采用 Dindo-Clavien 分类。
中位随访时间为 16.1 年。485 名供体中，272 名（56.1%）做出了回应。大多数供体（>90%）报告他们的整体健康状况极好/良好，且捐赠对其职业生活无积极或负面影响。住院时间（LOS）与对职业生活的影响和恢复到基线功能有关（均 p = 0.046）。主要并发症与当前身体状况或恢复到基线正常状态无关（p = 0.06）。75 名供体（27.5%）表示不确定或不愿意再次捐赠。没有任何参数与再次捐赠的反应有关。在过去十年中，更快地恢复到基线功能和对职业生活的更积极影响可能是由于并发症发生率较低（均 p < 0.001）。
这是德国和土耳其人群进行活体肝移植后随访时间最长的报告。尽管存在回忆偏倚，但 LOS 与职业生活的负面影响和恢复到基线功能有关。后悔的感觉高于文献报道。这些长期影响应纳入供体讨论。
