Zaouak A, Jebali S, Chouchane H, Jelassi H
Research Laboratory On Energy and Matter for Nuclear Science Development (LR16CNSTN02), National Center for Nuclear Science and Technology, Sidi Thabet Technopark, 2020 Ariana, Tunisia.
Laboratoire National de Contrôle Des Médicaments, 11 Bis Rue Jebel Lakhdar Bab Saadoun, 1006 Tunis, Tunisia.
Int J Environ Sci Technol (Tehran). 2023;20(6):6815-6824. doi: 10.1007/s13762-022-04360-z. Epub 2022 Jul 7.
In this work, the effect of gamma irradiation emitted by Cobalt 60 source has been investigated for the degradation of hydroxychloroquine (HCQ). The monitoring of the gamma irradiation treatment of HCQ aqueous solutions was followed by UV-visible, chemical oxygen demand, total organic carbon (TOC) and LC/MS analyses. Effects of several important parameters such as concentration, dose rate and pH on the degradation efficiency were studied then evaluated. Achieved results showed that % TOC removal efficiency of 98.5 was obtained after 8 kGy absorbed dose which warrants HCQ mineralization. The process was found to be more efficient when the initial pollutant concentration was low, with higher dose rate and at neutral pH. Furthermore, HCQ degradation kinetic study revealed a pseudo-first-order kinetic. Additionally, based on by-products identified by LC/MS, a degradation mechanistic schema mediated through hydroxyl radicals generated by water radiolysis has been proposed. Finally, in order to check the potential industrial application viability the energy consuming was evaluated.
在这项工作中，研究了钴60源发出的γ辐射对羟氯喹（HCQ）降解的影响。通过紫外可见光谱、化学需氧量、总有机碳（TOC）和液相色谱/质谱分析对HCQ水溶液的γ辐射处理进行监测。研究并评估了浓度、剂量率和pH值等几个重要参数对降解效率的影响。取得的结果表明，在吸收剂量为8 kGy后，TOC去除效率达到98.5%，这保证了HCQ的矿化。发现当初始污染物浓度较低、剂量率较高且pH值为中性时，该过程效率更高。此外，HCQ降解动力学研究揭示了准一级动力学。此外，基于液相色谱/质谱鉴定的副产物，提出了一种通过水辐射分解产生的羟基自由基介导的降解机理图。最后，为了检验潜在的工业应用可行性，对能耗进行了评估。
