Saini Volga M, Liu Kaitlyn R, Surve Aishwarya Suryakant, Gupta Sanjeev, Gupta Ananya
Discipline of Physiology, School of Medicine, NUI Galway, H91TK33 Galway, Ireland.
Discipline of Pathology, School of Medicine, NUI Galway, H91TK33 Galway, Ireland.
J Diabetes Metab Disord. 2022 Jul 7;21(2):1819-1832. doi: 10.1007/s40200-022-01066-4. eCollection 2022 Dec.
MicroRNAs (miRNAs) have been shown to be altered in both CVD and T2DM and can have an application as diagnostic and prognostic biomarkers. miRNAs are released into circulation when the cardiomyocyte is subjected to injury and damage.
Measuring circulating miRNA levels in human plasma may be of great potential use for measuring the extent of damage to cardiomyocytes and response to exercise. This review is aimed to highlight the potential application of miRNAs as biomarkers of CVD progression in T2DM, and the impact of exercise on recovery.
The review aims to examine whether the health improvements following exercise in T2DM patients are reflective of changes in expression of plasma miRNAs. For this purpose, studies were identified from the literature that have established a correlation between diabetes, disease progression and plasma miRNA levels. We also reviewed studies which looked at the effect of exercise on plasma miRNA levels.
The review identified miRNA signatures that are affected by T2DM and DHD and a subset of these miRNAs that are also affected by different types of exercise. This approach helped us to identify those miRNAs whose expression and function can be altered by regular bouts of exercise.
miRNAs identified as part of this review can serve as tools to monitor the cardio-protective, anti-inflammatory and metabolic effects of exercise in people suffering from T2DM. Future research should focus on regulation of these miRNAs in T2DM and how they can be altered by appropriate exercise interventions.
The online version contains supplementary material available at 10.1007/s40200-022-01066-4.
微小RNA（miRNA）已被证明在心血管疾病（CVD）和2型糖尿病（T2DM）中均发生改变，并且可作为诊断和预后生物标志物应用。当心肌细胞受到损伤时，miRNA会释放到循环中。
测量人血浆中循环miRNA水平对于评估心肌细胞损伤程度和运动反应可能具有巨大潜在用途。本综述旨在强调miRNA作为T2DM中CVD进展生物标志物的潜在应用，以及运动对恢复的影响。
本综述旨在研究T2DM患者运动后健康状况的改善是否反映血浆miRNA表达的变化。为此，从文献中筛选出已确定糖尿病、疾病进展与血浆miRNA水平之间相关性的研究。我们还综述了研究运动对血浆miRNA水平影响的研究。
本综述确定了受T2DM和糖尿病性心肌病（DHD）影响的miRNA特征，并且这些miRNA中的一部分也受不同类型运动的影响。这种方法帮助我们确定了那些其表达和功能可通过定期运动而改变的miRNA。
作为本综述一部分而确定的miRNA可作为监测运动对T2DM患者心脏保护、抗炎和代谢作用的工具。未来研究应聚焦于T2DM中这些miRNA的调控以及它们如何通过适当的运动干预而改变。
在线版本包含可在10.1007/s40200-022-01066-4获取的补充材料。
