Laursen S O, Pedersen K E, Klitgaard N A
Dan Med Bull. 1987 Apr;34(2):115-7.
The influence of physical activity on the plasma digoxin concentration was investigated in 13 digitalised patients suffering from a variety of cardiac diseases. Plasma digoxin concentration was determined four times during two consecutive days. In the morning, the standing position and one hour of physical activity caused a consistent and significant decrease in the plasma digoxin concentration, the mean reduction being 26.7 percent. In the afternoon, no consistent changes of plasma digoxin concentration were observed during one hour's rest. Consequently, we suggest standardisation of the blood sampling procedure so that no blood collection takes place in the morning until the patient has been performing normal physical activity for at least one hour.
对13例患有各种心脏病且已使用洋地黄治疗的患者，研究了体力活动对血浆地高辛浓度的影响。在连续两天内，四次测定血浆地高辛浓度。早晨，站立位及1小时的体力活动导致血浆地高辛浓度持续且显著下降，平均降幅为26.7%。下午，1小时休息期间未观察到血浆地高辛浓度有一致变化。因此，我们建议规范采血程序，即早晨在患者进行至少1小时正常体力活动之前不进行采血。
