von Ardenne M, Reitnauer P G
Res Exp Med (Berl). 1979 Apr 23;175(1):7-18. doi: 10.1007/BF01851229.
Local tumor hyperthermia (42--43 degrees C) during moderate whole body hyperthermia (40 degrees C) and hyperglycemia (5 . 10(-3) g ml-1) led to an amplification of tumor hyperacidification of deltapH = 0,47 +/- 0,19 In 12 from 20 animals. As cause of this phenomenon the stimulation of glycolysis by temperature increase (van't Hoff's law) and the stop of microcirculation by hyperthermia plus decrease of erythrocyte flexibility was discussed 5 tumors regressed totally.
在中度全身热疗（40℃）和高血糖（5×10⁻³g/ml）期间进行局部肿瘤热疗（42 - 43℃），导致20只动物中有12只出现肿瘤超酸化增强，ΔpH = 0.47±0.19。讨论了温度升高刺激糖酵解（范特霍夫定律）以及热疗导致微循环停止和红细胞柔韧性降低作为这种现象的原因。5个肿瘤完全消退。
