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两亲性糖树状大分子：新型糖模拟支架，靶向碳水化合物结合蛋白。

Bola-Amphiphilic Glycodendrimers: New Carbohydrate-Mimicking Scaffolds to Target Carbohydrate-Binding Proteins.

机构信息

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research Innovative Drug Research Center School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China.

Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.

出版信息

Chemistry. 2022 Oct 18;28(58):e202201400. doi: 10.1002/chem.202201400. Epub 2022 Aug 26.

DOI:10.1002/chem.202201400
PMID:35820051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9804701/
Abstract

Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.

摘要

树状大分子是一种很有吸引力的支架，可用于构建具有独特多价协同作用的碳水化合物模拟物。我们在此报告了新型带有甘露糖和葡萄糖末端以及对活性氧响应的疏水性硫缩醛核心的棒状两亲性糖树突。独特的棒状两亲性特征使其与凝集素的结合比传统两亲性更强。此外，这些树突能够靶向细胞表面表达的甘露糖受体和葡萄糖转运体，从而实现有效的特异性细胞摄取。这突出了它们在靶向递送上的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/a68cb58c0a3a/CHEM-28-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/1afa32bcf742/CHEM-28-0-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/ccf5d808eb99/CHEM-28-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/0f585d13da13/CHEM-28-0-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/2306ac2896af/CHEM-28-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/af9b664fa033/CHEM-28-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/24a8348d9cfd/CHEM-28-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/a68cb58c0a3a/CHEM-28-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/1afa32bcf742/CHEM-28-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/8e510e4a5bac/CHEM-28-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/ccf5d808eb99/CHEM-28-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/0f585d13da13/CHEM-28-0-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/2306ac2896af/CHEM-28-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/af9b664fa033/CHEM-28-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/24a8348d9cfd/CHEM-28-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4199/9804701/a68cb58c0a3a/CHEM-28-0-g006.jpg

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Design, Synthetic Strategies, and Therapeutic Applications of Heterofunctional Glycodendrimers.杂臂糖树状大分子的设计、合成策略及治疗应用。
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Front Pharmacol. 2023 Mar 16;14:1159131. doi: 10.3389/fphar.2023.1159131. eCollection 2023.
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