Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
J Pharm Biomed Anal. 2022 Sep 20;219:114933. doi: 10.1016/j.jpba.2022.114933. Epub 2022 Jul 7.
Hydrocortisone (HC), as a common steroid hormone drug, is also one of the key intermediates involved in the synthesis of multiple steroid hormone drugs. Residual HC in pharmaceutical wastewater frequently pollutes environmental water as steroid hormone contaminant and possesses great threat to human health as well as sustainable development of the ecosystem. Herein, in order to develop a highly efficient adsorbent system for selective enrichment and detection of HC in pharmaceutical wastewater, a novel amino-functionalized aluminum-based metal organic frameworks (Al-MOFs@NH) mesoporous nanorod is fabricated, in which 2-aminoterephthalic acid plays a dual role as organic linker and functional modification unit. The resultant Al-MOFs@NH not only exhibits stable mesoporous structure but also has large specific surface area (849.76 m g) and plentiful binding sites, which significantly increases the adsorption capacity for HC. Under the promotion of hydrogen bonding and hydrophobic interaction together, Al-MOFs@NH possesses high adsorption capacity (218.53 mg g) for HC, as well as shows satisfactory selectivity for HC and other steroid hormones. Moreover, a method using Al-MOFs@NH as solid phase extraction adsorbents combined with high performance liquid chromatography (HPLC) has been developed to specifically enrich and detect trace amount of HC in pharmaceutical wastewater. The developed method has a low limit of detection (LOD) (0.5×10 μg mL) and shows satisfactory recoveries for HC (75.9%-102.5%) with an acceptable relative standard deviation (RSD). These results demonstrate that the facile one-step preparation and excellent adsorption capacity makes Al-MOFs@NH attractive to capture and remove environmental steroid hormone pollutants. More importantly, the method proposed in this work is expected to provide a prospective solution for analysis of strong bioactive contaminants in pharmaceutical wastewater.
氢化可的松（HC）作为一种常见的甾体激素药物，也是多种甾体激素药物合成中涉及的关键中间体之一。药物废水中残留的 HC 作为甾体激素污染物频繁污染环境水，对人类健康以及生态系统的可持续发展构成了巨大威胁。在此，为了开发一种高效的吸附剂体系，用于选择性富集和检测药物废水中的 HC，我们制备了一种新型的氨基功能化铝基金属有机骨架（Al-MOFs@NH）介孔纳米棒，其中 2-氨基对苯二甲酸既作为有机连接体又作为功能修饰单元。所得的 Al-MOFs@NH 不仅具有稳定的介孔结构，而且具有大的比表面积（849.76 m g）和丰富的结合位点，这显著增加了对 HC 的吸附能力。在氢键和疏水相互作用的共同促进下，Al-MOFs@NH 对 HC 具有高的吸附容量（218.53 mg g），并且对 HC 和其他甾体激素表现出令人满意的选择性。此外，我们还开发了一种使用 Al-MOFs@NH 作为固相萃取吸附剂结合高效液相色谱（HPLC）的方法，用于特异性地富集和检测药物废水中痕量的 HC。所开发的方法具有低的检测限（LOD）（0.5×10 μg mL），并且对 HC 具有令人满意的回收率（75.9%-102.5%），相对标准偏差（RSD）可接受。这些结果表明，简便的一步法制备和优异的吸附能力使 Al-MOFs@NH 具有吸引力，可以用于捕获和去除环境中的甾体激素污染物。更重要的是，本工作中提出的方法有望为分析药物废水中的强生物活性污染物提供有前景的解决方案。
