Beardsley P M, Balster R L
Drug Alcohol Depend. 1987 Mar;19(2):121-9. doi: 10.1016/0376-8716(87)90050-0.
Four rhesus monkeys trained to press levers for intravenous cocaine infusions were tested with saline and minaprine [3-(2-morpholinoethylamino)-4-methyl-6-phenyl pyridazine dihydrochloride, 3-300 micrograms/kg per infusion] during daily 1-h sessions. From 4 to over 25 times more cocaine infusions were obtained than saline infusions during baseline sessions. When minaprine was substituted for cocaine, none of the tested doses maintained responding above saline levels in two of the monkeys. Some doses of minaprine did maintain responding slightly above those of saline in the other two monkeys; however, the average number of infusions and the within-session time course of minaprine infusions at these doses were markedly more similar to saline than to that of cocaine. It was concluded that minaprine did not serve as a positive reinforcer under the present experimental conditions for any of the monkeys and it was predicted that minaprine would have low liability for recreational use in humans.
对四只经过训练通过按压杠杆获取静脉注射可卡因的恒河猴，在每天1小时的实验时段内，用生理盐水和米那普明[3-(2-吗啉代乙氨基)-4-甲基-6-苯基哒嗪二盐酸盐，每次注射剂量为3 - 300微克/千克]进行测试。在基线期，获得的可卡因注射次数比生理盐水注射次数多4至25倍以上。当用米那普明替代可卡因时，在两只猴子中，所测试的任何剂量都未能使反应维持在高于生理盐水的水平。在另外两只猴子中，某些剂量的米那普明确实使反应略高于生理盐水；然而，这些剂量下米那普明注射的平均次数和时段内时间进程与生理盐水的更为相似，而与可卡因的明显不同。得出的结论是，在当前实验条件下，米那普明对任何一只猴子都不作为阳性强化物，并且预计米那普明在人类中用于娱乐用途的可能性较低。
