内过氧化物形成加氧酶的结构基础。
Structural basis for endoperoxide-forming oxygenases.
作者信息
Mori Takahiro, Abe Ikuro
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
Beilstein J Org Chem. 2022 Jun 21;18:707-721. doi: 10.3762/bjoc.18.71. eCollection 2022.
Endoperoxide natural products are widely distributed in nature and exhibit various biological activities. Due to their chemical features, endoperoxide and endoperoxide-derived secondary metabolites have attracted keen attention in the field of natural products and organic synthesis. In this review, we summarize the structural analyses, mechanistic investigations, and proposed reaction mechanisms of endoperoxide-forming oxygenases, including cyclooxygenase, fumitremorgin B endoperoxidase (FtmOx1), and the asnovolin A endoperoxygenase NvfI.
内过氧化物天然产物在自然界中广泛分布，并具有多种生物活性。由于其化学特性，内过氧化物及其衍生的次生代谢产物在天然产物和有机合成领域引起了密切关注。在本综述中，我们总结了内过氧化物形成氧化酶的结构分析、机理研究及提出的反应机制，包括环氧化酶、烟曲霉震颤素B内过氧化物酶（FtmOx1）和阿斯诺伏林A内过氧化物酶NvfI。
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