回复“关于内过氧化物合酶 FtmOx1 催化机制的结构见解”的通信。
Reply to Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1''.
机构信息
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
出版信息
Angew Chem Int Ed Engl. 2023 Sep 11;62(37):e202306059. doi: 10.1002/anie.202306059. Epub 2023 Aug 4.
The high-resolution X-ray crystal structure of the ternary complex FtmOx1 ⋅ 2OG ⋅ fumitremorgin B and the catalytic mechanism were recently reported by us (DOI 10.1002/anie.202112063). In their Correspondence, Zhang, Costello, Liu et al. criticize our work in several aspects. Herein, we address these questions one by one. These structural clarifications and new computational results further support the CarC-like mechanistic model.
我们最近报道了三元复合物 FtmOx1 ⋅ 2OG ⋅ fumitremorgin B 的高分辨率 X 射线晶体结构和催化机制（DOI 10.1002/anie.202112063）。在他们的通信中，Zhang、Costello、Liu 等人在几个方面批评了我们的工作。在这里，我们逐一回答这些问题。这些结构上的澄清和新的计算结果进一步支持了类似 CarC 的机制模型。
Zotero 插件