Harada Takashi, Taniguchi Fuminori, Harada Tasuku
Department of Obstetrics and Gynecology Tottori University Faculty of Medicine Yonago Japan.
Reprod Med Biol. 2022 Jul 6;21(1):e12473. doi: 10.1002/rmb2.12473. eCollection 2022 Jan-Dec.
Reproductive-age women occasionally face the pathological condition of adenomyosis, which is often concurrent with endometriosis. It is believed that endometriosis and adenomyosis increases the risk of obstetric complications. Although new insights into the mechanism of obstetric complications due to endometriosis are emerging, there is little information on the etiology of adverse pregnancy outcomes in pregnant women with adenomyosis.
We performed a literature review focusing on the pathophysiological pathways of obstetric complications in women with adenomyosis using currently available basic and clinical studies. We used the internet search engines PubMed and Google Scholar to search for studies published between January 2000 and June 2021. We carefully read pertinent sections within each document to ensure relevancy.
The prevalence of adverse pregnancy outcomes in women with adenomyosis is increased after adjusting for conceiving by assisted reproductive technology. Thus, adenomyosis emerges as a relevant factor associated with several obstetric complications such as preterm birth, preterm premature rupture of membranes, placental abruption, small for gestational age/fetal growth restriction, and preeclampsia.
It is plausible that the impact of adenomyosis on pregnancy outcomes is not always the same; rather it is dependent on the degree of uterine involvement and subtypes.
育龄期女性偶尔会面临子宫腺肌病这一病理状况，该病常与子宫内膜异位症并发。据信，子宫内膜异位症和子宫腺肌病会增加产科并发症的风险。尽管关于子宫内膜异位症所致产科并发症机制的新见解不断涌现，但关于子宫腺肌病孕妇不良妊娠结局的病因却知之甚少。
我们利用现有的基础和临床研究，对子宫腺肌病女性产科并发症的病理生理途径进行了文献综述。我们使用互联网搜索引擎PubMed和谷歌学术搜索2000年1月至2021年6月期间发表的研究。我们仔细阅读了每份文献中的相关部分以确保相关性。
在通过辅助生殖技术受孕进行校正后，子宫腺肌病女性不良妊娠结局的发生率有所增加。因此，子宫腺肌病成为与几种产科并发症相关的一个因素，如早产、胎膜早破、胎盘早剥、小于胎龄儿/胎儿生长受限和子痫前期。
子宫腺肌病对妊娠结局的影响可能并不总是相同的；相反，它取决于子宫受累程度和亚型。
