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免疫与衰老中的生长分化因子-15

Growth Differentiation Factor-15 in Immunity and Aging.

作者信息

Pence Brandt D

机构信息

College of Health Sciences, University of Memphis, Memphis, TN, United States.

出版信息

Front Aging. 2022 Feb 9;3:837575. doi: 10.3389/fragi.2022.837575. eCollection 2022.

DOI:10.3389/fragi.2022.837575
PMID:35821815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9261309/
Abstract

Aging increases susceptibility to and severity of a variety of chronic and infectious diseases. Underlying this is dysfunction of the immune system, including chronic increases in low-grade inflammation (inflammaging) and age-related immunosuppression (immunosenescence). Growth differentiation factor-15 (GDF-15) is a stress-, infection-, and inflammation-induced cytokine which is increased in aging and suppresses immune responses. This mini review briefly covers existing knowledge on the immunoregulatory and anti-inflammatory roles of GDF-15, as well as its potential importance in aging and immune function.

摘要

衰老会增加对多种慢性疾病和传染病的易感性及患病严重程度。其根本原因是免疫系统功能失调，包括低度炎症（炎症衰老）的慢性增加和与年龄相关的免疫抑制（免疫衰老）。生长分化因子15（GDF-15）是一种由应激、感染和炎症诱导产生的细胞因子，在衰老过程中水平升高，并抑制免疫反应。这篇小型综述简要介绍了关于GDF-15的免疫调节和抗炎作用的现有知识，以及它在衰老和免疫功能中的潜在重要性。