Azuma Kotaro, Osuka Yosuke, Kojima Narumi, Sasai Hiroyuki, Kim Hunkyung, Inoue Satoshi
Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Front Aging. 2022 Apr 13;3:865178. doi: 10.3389/fragi.2022.865178. eCollection 2022.
Frailty is the state of having a reduced ability to recover from stress. Intervention in frailty is important for fulfilling healthy longevity. Vitamin K is a fat-soluble vitamin contained in vegetables and fermented foods. Although vitamin K is shown to be associated with several age-related diseases, studies on the association of vitamin K intake and frailty in the elderly population are limited. In the present study, a total of 800 community-dwelling older adults (mean age = 75.9) were recruited for a comprehensive geriatric health examination, including frailty evaluation based on the Japanese version of the Cardiovascular Health Study criteria. Serum concentrations of total osteocalcin (OC) and undercarboxylated osteocalcin (ucOC) were measured. The ratio of ucOC and OC (ucOC/OC), which reflects vitamin K insufficiency, was calculated for each participant, and the values were divided into quartiles. A binary logistic regression analysis was performed to evaluate the risk of frailty for each quartile of ucOC/OC, with the lowest quartile as the reference. Significant association of frailty and the highest quartile of ucOC/OC was found with the odds ratio of 2.49 ( = 0.023) with adjustment with age, sex, body mass index, dietary intake, and several clinical characteristics. When the analysis was repeated in each component of frailty, the highest quartiles of ucOC/OC had the tendency of association with "slow walking speed" and "low activity." Our findings demonstrated the association between vitamin K insufficiency and frailty in the elderly population. Our analysis also suggests that vitamin K insufficiency could be associated with selected components of frailty.
衰弱是指从压力中恢复的能力下降的状态。对衰弱进行干预对于实现健康长寿很重要。维生素K是一种存在于蔬菜和发酵食品中的脂溶性维生素。尽管维生素K已被证明与多种与年龄相关的疾病有关，但关于老年人群维生素K摄入量与衰弱之间关联的研究却很有限。在本研究中，总共招募了800名社区居住的老年人（平均年龄 = 75.9岁）进行全面的老年健康检查，包括根据日本版心血管健康研究标准进行衰弱评估。测量了血清总骨钙素（OC）和未羧化骨钙素（ucOC）的浓度。计算了每位参与者反映维生素K不足的ucOC与OC的比值（ucOC/OC），并将这些值分为四分位数。进行二元逻辑回归分析以评估ucOC/OC每个四分位数的衰弱风险，以最低四分位数作为参考。在对年龄、性别、体重指数、饮食摄入和一些临床特征进行调整后，发现衰弱与ucOC/OC的最高四分位数之间存在显著关联，比值比为2.49（P = 0.023）。当在衰弱的每个组成部分中重复进行分析时，ucOC/OC的最高四分位数有与“行走速度慢”和“活动量低”相关联的趋势。我们的研究结果证明了老年人群中维生素K不足与衰弱之间的关联。我们的分析还表明，维生素K不足可能与衰弱的某些特定组成部分有关。
