Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
J Bone Miner Metab. 2023 Nov;41(6):817-821. doi: 10.1007/s00774-023-01457-4. Epub 2023 Jul 31.
Vitamin K is a fat-soluble vitamin discovered as an essential factor for blood coagulation. It is suggested that vitamin K can benefit several aging-related diseases, including osteoporosis, osteoarthritis, and dementia. We previously reported the cross-sectional association of vitamin K insufficiency with frailty in community-dwelling older adults.
In October 2020, a health examination of community-dwelling older adults (The Otassha Study) was performed, including frailty evaluation and blood tests. We used a ucOC and OC ratio (ucOC/OC) to indicate vitamin K insufficiency. One year later, we conducted a follow-up evaluation of frailty on 518 people who were not frail at baseline. The serum ucOC/OC at the baseline examination was divided into quartiles (Q1, Q2, Q3, and Q4). Odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariate binary logistic regression for each quartile of ucOC/OC to determine the risk of incident frailty in the follow-up study, with the lowest quartile (Q1) as the reference.
Among the 518 older adults who were not frail at baseline, 66 people (12.7%) became frail in the follow-up study. In the multivariate binary logistic regression analysis, setting the lowest quartile of ucOC/OC (Q1) as a reference, the OR of the incident frailty in the highest quartile (Q4) was 2.53 (95% CI 1.07, 4.92) which was significantly different from Q1.
The findings of this longitudinal study suggest that vitamin K insufficiency has nutritional importance in predicting the future incidence of frailty in the Japanese older adult population.
维生素 K 是一种脂溶性维生素，作为血液凝固的必需因素而被发现。有研究表明，维生素 K 可能有益于多种与衰老相关的疾病，包括骨质疏松症、骨关节炎和痴呆症。我们之前报道过社区居住的老年人中维生素 K 不足与虚弱的横断面关联。
2020 年 10 月，对社区居住的老年人（Otassha 研究）进行了健康检查，包括虚弱评估和血液检查。我们使用 ucOC 和 OC 比值（ucOC/OC）来表示维生素 K 不足。一年后，我们对基线时无虚弱的 518 人进行了虚弱的随访评估。将基线检查时的血清 ucOC/OC 分为四等分（Q1、Q2、Q3 和 Q4）。使用多变量二项逻辑回归计算每个 ucOC/OC 四分位数的优势比（OR）和 95%置信区间（CI），以确定随访研究中发生虚弱的风险，以最低四分位数（Q1）为参考。
在基线时无虚弱的 518 位老年人中，有 66 人（12.7%）在随访研究中变得虚弱。在多变量二项逻辑回归分析中，以最低四分位数（Q1）为参考，最高四分位数（Q4）的虚弱发生率的 OR 为 2.53（95%CI 1.07，4.92），与 Q1 有显著差异。
这项纵向研究的结果表明，维生素 K 不足在预测日本老年人群未来虚弱的发生方面具有营养重要性。
